PURPOSE: To assess how vitamin D status is associated with health-related quality of life (HRQOL) among older residents of Canada. DESIGN: We analysed baseline data of 1,493 Canadians aged 50 years and over in Alberta on HRQOL (EQ-5D-5L) and serum 25-hydroxyvitamin D (25(OH)D) as a measure of vitamin D status. We applied multivariable regression methods to examine the association between vitamin D status and each of the five dimensions and the summary index of the EQ-5D-5L. RESULTS: Participants with higher serum 25(OH)D levels were significantly less likely to report problems with mobility, usual activities, and depression and anxiety. Specifically, age- and gender-adjusted odds ratios for reporting problems with mobility, usual activities, and depression and anxiety were 0.58 (95 % confidence interval 0.44-0.78), 0.67 (0.50-0.89), and 0.67 (0.51-0.88) per 100 nmol/L increase in 25(OH)D, respectively. No significant associations were observed for problems with self-care and with pain and discomfort. HRQOL scores combining the responses of each of the five dimensions increased significantly with increasing serum 25(OH)D levels. CONCLUSIONS: This is the first study to reveal the importance of vitamin D for the five dimensions of HRQOL in a community-based sample. The observed associations of vitamin D and HRQOL call for intervention studies to strengthen the evidence of the potential benefits of vitamin D supplementation for HRQOL among older adults.
PURPOSE: To assess how vitamin D status is associated with health-related quality of life (HRQOL) among older residents of Canada. DESIGN: We analysed baseline data of 1,493 Canadians aged 50 years and over in Alberta on HRQOL (EQ-5D-5L) and serum 25-hydroxyvitamin D (25(OH)D) as a measure of vitamin D status. We applied multivariable regression methods to examine the association between vitamin D status and each of the five dimensions and the summary index of the EQ-5D-5L. RESULTS:Participants with higher serum 25(OH)D levels were significantly less likely to report problems with mobility, usual activities, and depression and anxiety. Specifically, age- and gender-adjusted odds ratios for reporting problems with mobility, usual activities, and depression and anxiety were 0.58 (95 % confidence interval 0.44-0.78), 0.67 (0.50-0.89), and 0.67 (0.51-0.88) per 100 nmol/L increase in 25(OH)D, respectively. No significant associations were observed for problems with self-care and with pain and discomfort. HRQOL scores combining the responses of each of the five dimensions increased significantly with increasing serum 25(OH)D levels. CONCLUSIONS: This is the first study to reveal the importance of vitamin D for the five dimensions of HRQOL in a community-based sample. The observed associations of vitamin D and HRQOL call for intervention studies to strengthen the evidence of the potential benefits of vitamin D supplementation for HRQOL among older adults.
Authors: Lisa B Signorello; Joseph K McLaughlin; Loren Lipworth; Søren Friis; Henrik Toft Sørensen; William J Blot Journal: Am J Ther Date: 2002 May-Jun Impact factor: 2.688
Authors: P Lips; A Wiersinga; F C van Ginkel; M J Jongen; J C Netelenbos; W H Hackeng; P D Delmas; W J van der Vijgh Journal: J Clin Endocrinol Metab Date: 1988-10 Impact factor: 5.958
Authors: Robert P Heaney; Christine B French; Stacie Nguyen; Mia Ferreira; Leo L Baggerly; Ludovic Brunel; Paul Veugelers Journal: Adv Nutr Date: 2013-05-01 Impact factor: 8.701
Authors: K Renerts; K Fischer; B Dawson-Hughes; E J Orav; G Freystaetter; H-P Simmen; H-C Pape; A Egli; R Theiler; H A Bischoff-Ferrari Journal: Qual Life Res Date: 2019-02-09 Impact factor: 4.147
Authors: Nathalia Regina Sabatini Gandolfi; Jose Eduardo Corrente; Alberto De Vitta; Loraine Gollino; Gláucia Maria Ferreira da Silva Mazeto Journal: Qual Life Res Date: 2019-09-11 Impact factor: 4.147