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Literature DB >> 2474678

Mutational analysis of the human immunodeficiency virus vpr open reading frame.

K Ogawa¹, R Shibata, T Kiyomasu, I Higuchi, Y Kishida, A Ishimoto, A Adachi.

Abstract

Mutations were introduced by recombinant DNA techniques into the vpr open reading frame of an infectious molecular clone of human immunodeficiency virus type 1. The effect of these changes on the replicative and cytopathologic properties of the virus recovered from transfected cells was studied in several human CD4+ lymphocyte cell lines. In all cases, mutant viruses were infectious and cytopathic. However, when a low-input dose was used, mutants grew significantly more slowly than the wild-type virus. The growth kinetics of vpr mutants were distinct from those of vif and vpu mutants.

Entities: Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2474678 PMCID： PMC251018

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

36 in total

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Journal: Science Date: 1985-02-01 Impact factor: 47.728

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Authors: S Wain-Hobson; P Sonigo; O Danos; S Cole; M Alizon
Journal: Cell Date: 1985-01 Impact factor: 41.582

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Authors: M A Muesing; D H Smith; C D Cabradilla; C V Benton; L A Lasky; D J Capon
Journal: Nature Date: 1985 Feb 7-13 Impact factor: 49.962

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Journal: Science Date: 1985-01-11 Impact factor: 47.728

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Authors: N Ahmad; S Venkatesan
Journal: Science Date: 1988-09-16 Impact factor: 47.728

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Authors: F Sanger; S Nicklen; A R Coulson
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

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Authors: F Barré-Sinoussi; J C Chermann; F Rey; M T Nugeyre; S Chamaret; J Gruest; C Dauguet; C Axler-Blin; F Vézinet-Brun; C Rouzioux; W Rozenbaum; L Montagnier
Journal: Science Date: 1983-05-20 Impact factor: 47.728

9. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS.

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Journal: Science Date: 1984-05-04 Impact factor: 47.728

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Authors: J A Levy; A D Hoffman; S M Kramer; J A Landis; J M Shimabukuro; L S Oshiro
Journal: Science Date: 1984-08-24 Impact factor: 47.728

81 in total

1. Impairment of human immunodeficiency virus type 1 (HIV-1) entry into Jurkat T cells by constitutive expression of the HIV-1 vpr protein: role of CD4 down-modulation.

Authors: L Conti; B Varano; M C Gauzzi; P Matarrese; M Federico; W Malorni; F Belardelli; S Gessani
Journal: J Virol Date: 2000-11 Impact factor: 5.103

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Authors: N Hattori; F Michaels; K Fargnoli; L Marcon; R C Gallo; G Franchini
Journal: Proc Natl Acad Sci U S A Date: 1990-10 Impact factor: 11.205

Review 3. Mechanism of action of regulatory proteins encoded by complex retroviruses.

Authors: B R Cullen
Journal: Microbiol Rev Date: 1992-09

4. Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinants.

Authors: P Westervelt; T Henkel; D B Trowbridge; J Orenstein; J Heuser; H E Gendelman; L Ratner
Journal: J Virol Date: 1992-06 Impact factor: 5.103

5. Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells.

Authors: R Shibata; M Kawamura; H Sakai; M Hayami; A Ishimoto; A Adachi
Journal: J Virol Date: 1991-07 Impact factor: 5.103

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Authors: F Re; D Braaten; E K Franke; J Luban
Journal: J Virol Date: 1995-11 Impact factor: 5.103

7. A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particles.

Authors: Y L Lu; R P Bennett; J W Wills; R Gorelick; L Ratner
Journal: J Virol Date: 1995-11 Impact factor: 5.103

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Authors: V Jubier-Maurin; P Sarni-Manchado; F Veas; N Vidal; F Bibollet-Ruche; J P Durand; A Galat-Luong; G Cuny
Journal: J Virol Date: 1995-11 Impact factor: 5.103

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Authors: Z Matsuda; X Yu; Q C Yu; T H Lee; M Essex
Journal: Proc Natl Acad Sci U S A Date: 1993-04-15 Impact factor: 11.205

10. A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects.

Authors: I G Macreadie; L A Castelli; D R Hewish; A Kirkpatrick; A C Ward; A A Azad
Journal: Proc Natl Acad Sci U S A Date: 1995-03-28 Impact factor: 11.205