Literature DB >> 24739740

DEP domains: structurally similar but functionally different.

Sarah V Consonni1, Madelon M Maurice2, Johannes L Bos1.   

Abstract

The Dishevelled, EGL-10 and pleckstrin (DEP) domain is a globular protein domain that is present in about ten human protein families with well-defined structural features. A picture is emerging that DEP domains mainly function in the spatial and temporal control of diverse signal transduction events by recruiting proteins to the plasma membrane. DEP domains can interact with various partners at the membrane, including phospholipids and membrane receptors, and their binding is subject to regulation.

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Year:  2014        PMID: 24739740     DOI: 10.1038/nrm3791

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN: 1471-0072            Impact factor:   94.444


  52 in total

Review 1.  SH2 domains, interaction modules and cellular wiring.

Authors:  T Pawson; G D Gish; P Nash
Journal:  Trends Cell Biol       Date:  2001-12       Impact factor: 20.808

Review 2.  Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?

Authors:  Marek Mlodzik
Journal:  Trends Genet       Date:  2002-11       Impact factor: 11.639

3.  Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily.

Authors:  Concepcion Civera; Bernd Simon; Gunter Stier; Michael Sattler; Maria J Macias
Journal:  Proteins       Date:  2005-02-01

Review 4.  Wnt regulation of planar cell polarity (PCP).

Authors:  Bo Gao
Journal:  Curr Top Dev Biol       Date:  2012       Impact factor: 4.897

5.  Evolution of the regulators of G-protein signaling multigene family in mouse and human.

Authors:  David A Sierra; Debra J Gilbert; Deborah Householder; Nick V Grishin; Kan Yu; Pallavi Ukidwe; Sheryll A Barker; Wei He; Theodore G Wensel; Glen Otero; Greg Brown; Neal G Copeland; Nancy A Jenkins; Thomas M Wilkie
Journal:  Genomics       Date:  2002-02       Impact factor: 5.736

6.  Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Authors:  Maria Soledad Sosa; Cynthia Lopez-Haber; Chengfeng Yang; Hongbin Wang; Mark A Lemmon; John M Busillo; Jiansong Luo; Jeffrey L Benovic; Andres Klein-Szanto; Hiroshi Yagi; J Silvio Gutkind; Ramon E Parsons; Marcelo G Kazanietz
Journal:  Mol Cell       Date:  2010-12-22       Impact factor: 17.970

Review 7.  GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins.

Authors:  E M Ross; T M Wilkie
Journal:  Annu Rev Biochem       Date:  2000       Impact factor: 23.643

8.  The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.

Authors:  Simone L Sandiford; Vladlen Z Slepak
Journal:  Biochemistry       Date:  2009-03-17       Impact factor: 3.162

9.  Conformational stability studies of the pleckstrin DEP domain: definition of the domain boundaries.

Authors:  A Kharrat; S Millevoi; E Baraldi; C P Ponting; P Bork; A Pastore
Journal:  Biochim Biophys Acta       Date:  1998-06-11

10.  The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization.

Authors:  Thomas Schwarz-Romond; Marc Fiedler; Naoki Shibata; P Jonathan G Butler; Akira Kikuchi; Yoshiki Higuchi; Mariann Bienz
Journal:  Nat Struct Mol Biol       Date:  2007-05-27       Impact factor: 15.369

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  27 in total

1.  DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis.

Authors:  Ataman Sendoel; Simona Maida; Xue Zheng; Youjin Teo; Lilli Stergiou; Carlo-Alberto Rossi; Deni Subasic; Sergio M Pinto; Jason M Kinchen; Moyin Shi; Steffen Boettcher; Joel N Meyer; Markus G Manz; Daniele Bano; Michael O Hengartner
Journal:  Nat Cell Biol       Date:  2014-07-27       Impact factor: 28.824

2.  The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.

Authors:  Sandeep K Ravala; Jesse B Hopkins; Caroline B Plescia; Samantha R Allgood; Madison A Kane; Jennifer N Cash; Robert V Stahelin; John J G Tesmer
Journal:  J Biol Chem       Date:  2020-07-13       Impact factor: 5.157

3.  Anti-tubulins DEPendably induce apoptosis.

Authors:  Daniel P Denning; Takashi Hirose
Journal:  Nat Cell Biol       Date:  2014-08       Impact factor: 28.824

Review 4.  PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.

Authors:  Sophie M Hapak; Carla V Rothlin; Sourav Ghosh
Journal:  Cell Mol Life Sci       Date:  2018-04-25       Impact factor: 9.261

5.  Identification of the GTPase-activating protein DEP domain containing 1B (DEPDC1B) as a transcriptional target of Pitx2.

Authors:  Di Wu; Xiaoxi Zhu; Kevin Jimenez-Cowell; Alexander J Mold; Christopher C Sollecito; Nicholas Lombana; Meng Jiao; Qize Wei
Journal:  Exp Cell Res       Date:  2015-02-19       Impact factor: 3.905

6.  Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?

Authors:  Miroslav Micka; Vítězslav Bryja
Journal:  Handb Exp Pharmacol       Date:  2021

7.  The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-κB activation.

Authors:  Egildo Luca D'Andrea; Angela Ferravante; Ivan Scudiero; Tiziana Zotti; Carla Reale; Maddalena Pizzulo; Luigi Regenburgh De La Motte; Chiara De Maio; Pellegrino Mazzone; Gianluca Telesio; Pasquale Vito; Romania Stilo
Journal:  PLoS One       Date:  2014-12-26       Impact factor: 3.240

Review 8.  The cellular story of dishevelleds.

Authors:  Anja Kafka; Sandra Bašić-Kinda; Nives Pećina-Šlaus
Journal:  Croat Med J       Date:  2014-10       Impact factor: 1.351

9.  The Ancient Link between G-Protein-Coupled Receptors and C-Terminal Phospholipid Kinase Domains.

Authors:  D Johan van den Hoogen; Harold J G Meijer; Michael F Seidl; Francine Govers
Journal:  mBio       Date:  2018-01-23       Impact factor: 7.867

10.  Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.

Authors:  Melissa V Gammons; Miha Renko; Christopher M Johnson; Trevor J Rutherford; Mariann Bienz
Journal:  Mol Cell       Date:  2016-09-29       Impact factor: 17.970

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