Literature DB >> 25082198

Anti-tubulins DEPendably induce apoptosis.

Daniel P Denning1, Takashi Hirose1.   

Abstract

Anti-tubulin drugs are life-saving chemotherapeutics that kill cancer cells by stabilizing or disrupting microtubules. Despite their clinical utility, the molecular mechanisms by which anti-tubulins cause apoptotic cell death remain poorly understood. It is now shown that microtubule disruption can inhibit anti-apoptotic Bcl-2 family proteins through an evolutionarily conserved signalling axis involving DEPDC1 (LET-99 in Caenorhabditis elegans) and JNK.

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Year:  2014        PMID： 25082198     DOI： 10.1038/ncb3012

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  14 in total

1.  A first insight into the molecular mechanisms of apoptosis.

Authors:  Junying Yuan; H Robert Horvitz
Journal:  Cell       Date:  2004-01-23       Impact factor: 41.582

Review 2.  Microtubules as a target for anticancer drugs.

Authors:  Mary Ann Jordan; Leslie Wilson
Journal:  Nat Rev Cancer       Date:  2004-04       Impact factor: 60.716

3.  LET-99, GOA-1/GPA-16, and GPR-1/2 are required for aster-positioned cytokinesis.

Authors:  Henrik Bringmann; Carrie R Cowan; Jun Kong; Anthony A Hyman
Journal:  Curr Biol       Date:  2006-12-28       Impact factor: 10.834

Review 4.  Targeted anti-mitotic therapies: can we improve on tubulin agents?

Authors:  Jeffrey R Jackson; Denis R Patrick; Mohammed M Dar; Pearl S Huang
Journal:  Nat Rev Cancer       Date:  2007-02       Impact factor: 60.716

Review 5.  DEP domains: structurally similar but functionally different.

Authors:  Sarah V Consonni; Madelon M Maurice; Johannes L Bos
Journal:  Nat Rev Mol Cell Biol       Date:  2014-04-16       Impact factor: 94.444

6.  Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance.

Authors:  W B Derry; A P Putzke; J H Rothman
Journal:  Science       Date:  2001-09-13       Impact factor: 47.728

7.  Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

Authors:  Ingrid E Wertz; Saritha Kusam; Cynthia Lam; Toru Okamoto; Wendy Sandoval; Daniel J Anderson; Elizabeth Helgason; James A Ernst; Mike Eby; Jinfeng Liu; Lisa D Belmont; Josh S Kaminker; Karen M O'Rourke; Kanan Pujara; Pawan Bir Kohli; Adam R Johnson; Mark L Chiu; Jennie R Lill; Peter K Jackson; Wayne J Fairbrother; Somasekar Seshagiri; Mary J C Ludlam; Kevin G Leong; Erin C Dueber; Heather Maecker; David C S Huang; Vishva M Dixit
Journal:  Nature       Date:  2011-03-03       Impact factor: 49.962

8.  Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5.

Authors:  Jue Shi; James D Orth; Tim Mitchison
Journal:  Cancer Res       Date:  2008-05-01       Impact factor: 12.701

9.  SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.

Authors:  Hiroyuki Inuzuka; Shavali Shaik; Ichiro Onoyama; Daming Gao; Alan Tseng; Richard S Maser; Bo Zhai; Lixin Wan; Alejandro Gutierrez; Alan W Lau; Yonghong Xiao; Amanda L Christie; Jon Aster; Jeffrey Settleman; Steven P Gygi; Andrew L Kung; Thomas Look; Keiichi I Nakayama; Ronald A DePinho; Wenyi Wei
Journal:  Nature       Date:  2011-03-03       Impact factor: 49.962

10.  LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos.

Authors:  Meng-Fu Bryan Tsou; Adam Hayashi; Leah R DeBella; Garth McGrath; Lesilee S Rose
Journal:  Development       Date:  2002-10       Impact factor: 6.868
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  8 in total

1.  Functional analysis of the DEPDC1 oncoantigen in malignant glioma and brain tumor initiating cells.

Authors:  Ryogo Kikuchi; Oltea Sampetrean; Hideyuki Saya; Kazunari Yoshida; Masahiro Toda
Journal:  J Neurooncol       Date:  2017-05-29       Impact factor: 4.130

2.  DEPDC1 is a novel cell cycle related gene that regulates mitotic progression.

Authors:  Yan Mi; Chundong Zhang; Youquan Bu; Ying Zhang; Longxia He; Hongxia Li; Huifang Zhu; Yi Li; Yunlong Lei; Jiang Zhu
Journal:  BMB Rep       Date:  2015-07       Impact factor: 4.778

3.  From fighting depression to conquering tumors: a novel tricyclic thiazepine compound as a tubulin polymerization inhibitor.

Authors:  Y Mu; Y Liu; J Xiang; Q Zhang; S Zhai; D P Russo; H Zhu; X Bai; B Yan
Journal:  Cell Death Dis       Date:  2016-03-17       Impact factor: 8.469

4.  Identification of DEP domain-containing proteins by a machine learning method and experimental analysis of their expression in human HCC tissues.

Authors:  Zhijun Liao; Xinrui Wang; Yeting Zeng; Quan Zou
Journal:  Sci Rep       Date:  2016-12-21       Impact factor: 4.379

5.  Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity.

Authors:  Alexis Courbet; Nicole Bec; Caroline Constant; Christian Larroque; Martine Pugniere; Safia El Messaoudi; Zahraa Zghaib; Sonia Khier; Carine Deleuze-Masquefa; Florence Gattacceca
Journal:  PLoS One       Date:  2017-08-10       Impact factor: 3.240

6.  Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells.

Authors:  Cody Paiva; J Claire Godbersen; Ryan S Soderquist; Taylor Rowland; Sumner Kilmarx; Stephen E Spurgeon; Jennifer R Brown; Sreesha P Srinivasa; Alexey V Danilov
Journal:  PLoS One       Date:  2015-11-25       Impact factor: 3.240

7.  Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.

Authors:  Scott W Simpkins; Justin Nelson; Raamesh Deshpande; Sheena C Li; Jeff S Piotrowski; Erin H Wilson; Abraham A Gebre; Hamid Safizadeh; Reika Okamoto; Mami Yoshimura; Michael Costanzo; Yoko Yashiroda; Yoshikazu Ohya; Hiroyuki Osada; Minoru Yoshida; Charles Boone; Chad L Myers
Journal:  PLoS Comput Biol       Date:  2018-10-30       Impact factor: 4.475

8.  Chemoradiation impairs myofiber hypertrophic growth in a pediatric tumor model.

Authors:  Nicole D Paris; Jacob G Kallenbach; John F Bachman; Roméo S Blanc; Carl J Johnston; Eric Hernady; Jacqueline P Williams; Joe V Chakkalakal
Journal:  Sci Rep       Date:  2020-11-11       Impact factor: 4.379
  8 in total

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