PURPOSE: Carotid pulse wave velocity (PWV) is considered as a surrogate marker for carotid stiffness and its assessment is increasingly being used in clinical practice. However, at the moment, its estimation needs specific equipment and a moderate level of technical expertise; moreover, it is based on a mathematical model. The aim of this study was to validate a new system for non-invasive and model-free carotid PWV assessment based on accelerometric sensors by comparison with currently used techniques. METHODS: Accelerometric PWV (accPWV) values were obtained in 97 volunteers free of cardiovascular disease (age 24-85 years) and compared with standard ultrasound-based carotid stiffness parameters, such as carotid PWV (cPWV), relative distension (relD) and distensibility coefficient (DC). Moreover, the comparison between accPWV measurements and carotid-femoral PWV (cfPWV) was performed. RESULTS: Accelerometric PWV evaluations showed a significant correlation with cPWV measurements (R = 0.67), relD values (R = 0.66) and DC assessments (R = 0.64). These values were also significantly correlated with cfPWV evaluations (R = 0.46). In addition, the first attempt success rate was equal to 76.8 %. CONCLUSIONS: The accelerometric system allows a simple and quick local carotid stiffness evaluation and the values obtained with this system are significantly correlated with known carotid stiffness biomarkers. Therefore, the presented device could provide a concrete opportunity for an easy carotid stiffness evaluation even in clinical practice.
PURPOSE: Carotid pulse wave velocity (PWV) is considered as a surrogate marker for carotid stiffness and its assessment is increasingly being used in clinical practice. However, at the moment, its estimation needs specific equipment and a moderate level of technical expertise; moreover, it is based on a mathematical model. The aim of this study was to validate a new system for non-invasive and model-free carotid PWV assessment based on accelerometric sensors by comparison with currently used techniques. METHODS: Accelerometric PWV (accPWV) values were obtained in 97 volunteers free of cardiovascular disease (age 24-85 years) and compared with standard ultrasound-based carotid stiffness parameters, such as carotid PWV (cPWV), relative distension (relD) and distensibility coefficient (DC). Moreover, the comparison between accPWV measurements and carotid-femoral PWV (cfPWV) was performed. RESULTS: Accelerometric PWV evaluations showed a significant correlation with cPWV measurements (R = 0.67), relD values (R = 0.66) and DC assessments (R = 0.64). These values were also significantly correlated with cfPWV evaluations (R = 0.46). In addition, the first attempt success rate was equal to 76.8 %. CONCLUSIONS: The accelerometric system allows a simple and quick local carotid stiffness evaluation and the values obtained with this system are significantly correlated with known carotid stiffness biomarkers. Therefore, the presented device could provide a concrete opportunity for an easy carotid stiffness evaluation even in clinical practice.
Authors: Stephane Laurent; John Cockcroft; Luc Van Bortel; Pierre Boutouyrie; Cristina Giannattasio; Daniel Hayoz; Bruno Pannier; Charalambos Vlachopoulos; Ian Wilkinson; Harry Struijker-Boudier Journal: Eur Heart J Date: 2006-09-25 Impact factor: 29.983
Authors: Michael Barenbrock; Markus Kosch; Elke Jöster; Klaus Kisters; Karl-Heinz Rahn; Martin Hausberg Journal: J Hypertens Date: 2002-01 Impact factor: 4.844
Authors: Justin E Davies; Zachary I Whinnett; Darrel P Francis; Keith Willson; Rodney A Foale; Iqbal S Malik; Alun D Hughes; Kim H Parker; Jamil Mayet Journal: Am J Physiol Heart Circ Physiol Date: 2005-08-26 Impact factor: 4.733
Authors: El-Sayed H Ibrahim; Kevin R Johnson; Alan B Miller; Jean M Shaffer; Richard D White Journal: J Cardiovasc Magn Reson Date: 2010-05-11 Impact factor: 5.364
Authors: Evelien Hermeling; Koen D Reesink; Liselotte M Kornmann; Robert S Reneman; Arnold Pg Hoeks Journal: J Hypertens Date: 2009-10 Impact factor: 4.844
Authors: Jos J M Westenberg; Eveline P van Poelgeest; Paul Steendijk; Heynric B Grotenhuis; J W Jukema; Albert de Roos Journal: J Cardiovasc Magn Reson Date: 2012-01-09 Impact factor: 5.364