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Literature DB >> 2470430

Closed-time distribution of ionic channels. Analytical solution to a one-dimensional defect-diffusion model.

Abstract

A one-dimensional version of the model recently proposed by Läuger (1988) to explain the closed-time distribution of ionic channels in cell membranes is solved analytically. While the probability density f(t) for closed-time lengths may show a well-defined exponential behavior at short times, a power-law decay is predicted at long times. The influence of an additional random distribution of defects in the current-conducting protein is investigated and found to be dominating at long times. Explicit expressions that may be used for fitting experimental data are given for the closed-time distribution. Some of the available data are discussed and shown to be in good agreement with the predictions of the model.

Mesh：

Substances：
Ion Channels
Gramicidin

Year: 1989 PMID： 2470430 PMCID： PMC1330528 DOI： 10.1016/S0006-3495(89)82890-5

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

19 in total

10. Time course of reactions controlled and gated by intramolecular dynamics of proteins: predictions of the model of random walk on fractal lattices.

Authors: M Kurzynski; K Palacz; P Chelminiak
Journal: Proc Natl Acad Sci U S A Date: 1998-09-29 Impact factor: 11.205

Closed-time distribution of ionic channels. Analytical solution to a one-dimensional defect-diffusion model.

1. Single-channel currents recorded from membrane of denervated frog muscle fibres.

2. Brief closures of gramicidin A channels in lipid bilayer membranes.

3. Diffusion models of ion-channel gating and the origin of power-law distributions from single-channel recording.

4. Multiple conformational states of proteins: a molecular dynamics analysis of myoglobin.

5. Temperature-dependent X-ray diffraction as a probe of protein structural dynamics.

6. Crystallographic studies of the dynamic properties of lysozyme.

7. On the stochastic properties of single ion channels.

8. On the Williams-Watts function of dielectric relaxation.

9. Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate.

10. Rebinding and relaxation in the myoglobin pocket.

1. Ion channel gating: a first-passage time analysis of the Kramers type.

2. Gating of acetylcholine receptor channels: brownian motion across a broad transition state.

3. Percolation model of ionic channel dynamics.

4. Reptation theory of ion channel gating.

5. Using fractals to understand the opening and closing of ion channels.

6. Biological transport processes and space dimension.

7. Diffusion model in ion channel gating. Extension to agonist-activated ion channels.

8. Fractal mechanisms for the allosteric effects of proteins and enzymes.

9. Single ion channel models incorporating aggregation and time interval omission.

10. Time course of reactions controlled and gated by intramolecular dynamics of proteins: predictions of the model of random walk on fractal lattices.