Chunkit Fung1, Chintan Pandya2, Elizabeth Guancial3, Katia Noyes4, Deepak M Sahasrabudhe3, Edward M Messing5, Supriya G Mohile3. 1. Division of Medical Oncology, University of Rochester Medical Center, Rochester, New York. Electronic address: chunkit_fung@urmc.rochester.edu. 2. Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York. 3. Division of Medical Oncology, University of Rochester Medical Center, Rochester, New York. 4. Department of Surgery, University of Rochester Medical Center, Rochester, New York. 5. Department of Urology, University of Rochester Medical Center, Rochester, New York.
Abstract
PURPOSE: The impact of bladder cancer diagnosis on health related quality of life is poorly understood. We compared health related quality of life measures in patients before and after bladder cancer diagnosis. MATERIALS AND METHODS: We performed a cross-sectional study in 1,476 patients 65 years old or older with bladder cancer in the SEER-MHOS linkage database between 1998 and 2007 to assess differences in physical and mental component summary scores in 620 and 856 who completed a survey before and after bladder cancer diagnosis, respectively. To determine differences in physical and mental scores in the prediagnosis and post-diagnosis cohorts, we used ANOVA adjusting for baseline covariates. RESULTS: There were statistically significant differences in physical and mental component summary scores between the prediagnosis and post-diagnosis groups (-2.7, 95% CI -3.8, -1.7 vs -1.4, 95% CI -2.6, -0.3). In patients with nonmuscle invasive bladder cancer the physical and mental score differences were -1.9 (p <0.01) and -1.4 (p = 0.01), respectively. In those with muscle invasive bladder cancer there was a statistically and clinically significant difference in the physical but not the mental score (-5.3, p <0.01 vs -2.7, p = 0.07). This difference in the physical domain persisted up to 10 years after the diagnosis of muscle invasive bladder cancer. Patients with bladder cancer who had 4 or more comorbid medical conditions and 1 or more deficits in daily living activity were most at risk for low physical component summary scores. CONCLUSIONS: Future research into interventions to improve health related quality of life and methods to incorporate health related quality of life into decision making models are critical to improve outcomes in older patients with bladder cancer.
PURPOSE: The impact of bladder cancer diagnosis on health related quality of life is poorly understood. We compared health related quality of life measures in patients before and after bladder cancer diagnosis. MATERIALS AND METHODS: We performed a cross-sectional study in 1,476 patients 65 years old or older with bladder cancer in the SEER-MHOS linkage database between 1998 and 2007 to assess differences in physical and mental component summary scores in 620 and 856 who completed a survey before and after bladder cancer diagnosis, respectively. To determine differences in physical and mental scores in the prediagnosis and post-diagnosis cohorts, we used ANOVA adjusting for baseline covariates. RESULTS: There were statistically significant differences in physical and mental component summary scores between the prediagnosis and post-diagnosis groups (-2.7, 95% CI -3.8, -1.7 vs -1.4, 95% CI -2.6, -0.3). In patients with nonmuscle invasive bladder cancer the physical and mental score differences were -1.9 (p <0.01) and -1.4 (p = 0.01), respectively. In those with muscle invasive bladder cancer there was a statistically and clinically significant difference in the physical but not the mental score (-5.3, p <0.01 vs -2.7, p = 0.07). This difference in the physical domain persisted up to 10 years after the diagnosis of muscle invasive bladder cancer. Patients with bladder cancer who had 4 or more comorbid medical conditions and 1 or more deficits in daily living activity were most at risk for low physical component summary scores. CONCLUSIONS: Future research into interventions to improve health related quality of life and methods to incorporate health related quality of life into decision making models are critical to improve outcomes in older patients with bladder cancer.
Authors: Matthew E Nielsen; Shahrokh F Shariat; Pierre I Karakiewicz; Yair Lotan; Craig G Rogers; Gilad E Amiel; Patrick J Bastian; Amnon Vazina; Amit Gupta; Seth P Lerner; Arthur I Sagalowsky; Mark P Schoenberg; Ganesh S Palapattu Journal: Eur Urol Date: 2006-11-13 Impact factor: 20.096
Authors: Jason A Efstathiou; Kyounghwa Bae; William U Shipley; Donald S Kaufman; Michael P Hagan; Niall M Heney; Howard M Sandler Journal: J Clin Oncol Date: 2009-07-27 Impact factor: 44.544
Authors: Edward M Messing; Ralph Madeb; Changyong Feng; Laura Stephenson; Kennedy W Gilchrist; Terry Young; Jason Gee Journal: J Clin Oncol Date: 2009-03-30 Impact factor: 44.544
Authors: Ahrang Jung; Jamie L Crandell; Matthew E Nielsen; Sophia K Smith; Ashley Leak Bryant; Deborah K Mayer Journal: Support Care Cancer Date: 2022-04-18 Impact factor: 3.603
Authors: Ahrang Jung; Matthew E Nielsen; Jamie L Crandell; Mary H Palmer; Sophia K Smith; Ashley Leak Bryant; Deborah K Mayer Journal: BJU Int Date: 2019-09-25 Impact factor: 5.588
Authors: Elizabeth A Guancial; Breton Roussel; Derek P Bergsma; Kevin C Bylund; Deepak Sahasrabudhe; Edward Messing; Supriya G Mohile; Chunkit Fung Journal: Clin Interv Aging Date: 2015-06-10 Impact factor: 4.458