| Literature DB >> 24703889 |
Paolo Sansoni1, Rosanna Vescovini2, Francesco F Fagnoni3, Arne Akbar4, Ramon Arens5, Yen-Ling Chiu6, Luka Cičin-Šain7, Julie Dechanet-Merville8, Evelyna Derhovanessian9, Sara Ferrando-Martinez10, Claudio Franceschi11, Daniela Frasca12, Tamas Fulöp13, David Furman14, Effrossyni Gkrania-Klotsas15, Felicia Goodrum16, Beatrix Grubeck-Loebenstein17, Mikko Hurme18, Florian Kern19, Daniele Lilleri20, Miguel López-Botet21, Andrea B Maier22, Thomas Marandu7, Arnaud Marchant23, Catharina Matheï24, Paul Moss25, Aura Muntasell21, Ester B M Remmerswaal26, Natalie E Riddell4, Kathrin Rothe27, Delphine Sauce28, Eui-Cheol Shin29, Amanda M Simanek30, Megan J Smithey16, Cecilia Söderberg-Nauclér31, Rafael Solana32, Paul G Thomas33, Rene van Lier34, Graham Pawelec9, Janko Nikolich-Zugich35.
Abstract
Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on "CMV & Immunosenescence", held in Parma, Italy, 25-27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.Entities:
Keywords: Cytomegalovirus infection; Immune homeostasis; Immunosenescence; Pathologies of aging; Virus-host interaction
Mesh：
Year: 2014 PMID： 24703889 DOI： 10.1016/j.exger.2014.03.020
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032