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Literature DB >> 26611154

HSC Aging and Senescent Immune Remodeling.

Michael D Denkinger¹, Hanna Leins², Reinhold Schirmbeck³, Maria Carolina Florian⁴, Hartmut Geiger⁵.

Abstract

Aging-associated changes in the function of the immune system are referred to as senescent immune remodeling (SIR). Here we review the current understanding on the cellular and molecular mechanisms underlying SIR. We focus on aging-associated changes in T and B cells, and discuss recent evidence supporting the notion that aging of the hematopoietic stem cell (HSC) compartment directly contributes to SIR due to aging-associated alterations in stem cell differentiation. We conclude by outlining strategies to attenuate SIR, including approaches to rejuvenate HSCs, which may open new avenues for targeting SIR in the clinic.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2015 PMID： 26611154 PMCID： PMC4710174 DOI： 10.1016/j.it.2015.10.008

Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687

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