OBJECTIVES/HYPOTHESIS: Electromechanical reshaping (EMR) involves reshaping cartilage by mechanical deformation and delivering electric current to the area around the bend axis, causing local stress relaxation and permanent shape change. The mechanism of EMR is currently unclear, although preliminary studies suggest that voltage and application time are directly related to the concentration and diffusion of acid-base products within the treated tissue with little heat generation. This study aims to characterize local tissue pH changes following EMR and to demonstrate that local tissue pH changes are correlated with tissue damage and shape change. STUDY DESIGN: Ex vivo animal study involving EMR of rabbit nasal septal cartilage and biochemical estimation of tissue pH changes. METHODS: The magnitude and diffusion of acid-base chemical products in control (0V, 2 minutes), shape change (4V, 4 minutes; 6V, 1, 2, 4 minutes; 8V, 1, 2 minutes), and tissue damage (8V, 4, 5 minutes; 10V, 4, 5 minutes) parameters following EMR are approximated by analyzing local pH changes after pH indicator application. RESULTS: There is a direct relationship between total charge transfer and extent of acid-base product diffusion (P <0.05). A "pH transition zone" is seen surrounding the bend apex above 8V, 2 minutes. Colorimetric analysis suggests that small local pH changes (10(-8) hydrogen ions) are at least partly implicated in clinically efficacious EMR. CONCLUSIONS: These results provide additional insight into the translational applications of EMR, particularly the relationship among pH changes, shape change, and tissue injury, and are integral in optimizing this promising technology for clinical use.
OBJECTIVES/HYPOTHESIS: Electromechanical reshaping (EMR) involves reshaping cartilage by mechanical deformation and delivering electric current to the area around the bend axis, causing local stress relaxation and permanent shape change. The mechanism of EMR is currently unclear, although preliminary studies suggest that voltage and application time are directly related to the concentration and diffusion of acid-base products within the treated tissue with little heat generation. This study aims to characterize local tissue pH changes following EMR and to demonstrate that local tissue pH changes are correlated with tissue damage and shape change. STUDY DESIGN: Ex vivo animal study involving EMR of rabbit nasal septal cartilage and biochemical estimation of tissue pH changes. METHODS: The magnitude and diffusion of acid-base chemical products in control (0V, 2 minutes), shape change (4V, 4 minutes; 6V, 1, 2, 4 minutes; 8V, 1, 2 minutes), and tissue damage (8V, 4, 5 minutes; 10V, 4, 5 minutes) parameters following EMR are approximated by analyzing local pH changes after pH indicator application. RESULTS: There is a direct relationship between total charge transfer and extent of acid-base product diffusion (P <0.05). A "pH transition zone" is seen surrounding the bend apex above 8V, 2 minutes. Colorimetric analysis suggests that small local pH changes (10(-8) hydrogen ions) are at least partly implicated in clinically efficacious EMR. CONCLUSIONS: These results provide additional insight into the translational applications of EMR, particularly the relationship among pH changes, shape change, and tissue injury, and are integral in optimizing this promising technology for clinical use.
Authors: Amy Y Y Yau; Cyrus Manuel; Syed F Hussain; Dmitry E Protsenko; Brian J F Wong Journal: JAMA Facial Plast Surg Date: 2014 Jul-Aug Impact factor: 4.611
Authors: E Helidonis; E Sobol; G Kavvalos; J Bizakis; P Christodoulou; G Velegrakis; J Segas; V Bagratashvili Journal: Am J Otolaryngol Date: 1993 Nov-Dec Impact factor: 1.808
Authors: Michael W Keefe; Alexandre Rasouli; Sergey A Telenkov; Amir M Karamzadeh; Thomas E Milner; Roger L Crumley; Brian J F Wong Journal: Arch Facial Plast Surg Date: 2003 Jan-Feb
Authors: Ki-Hong Kevin Ho; Sergio H Diaz Valdes; Dmitriy E Protsenko; Guillermo Aguilar; Brian J F Wong Journal: Laryngoscope Date: 2003-11 Impact factor: 3.325
Authors: Dana M Hutchison; Amir A Hakimi; Ellen M Hong; Tiffany T Pham; Avin Wijayaweera; Soohong Seo; Yueqiao Qu; Melissa Bircan; Ryan Sivoraphonh; Brandyn Dunn; Chung-Ho Sun; Mark R Kobayashi; Sehwan Kim; Brian J F Wong Journal: Facial Plast Surg Aesthet Med Date: 2020-02-20
Authors: Karam W Badran; Cyrus T Manuel; Anthony Chin Loy; Christian Conderman; Yuk Yee Yau; Jennifer Lin; Tjoson Tjoa; Erica Su; Dmitriy Protsenko; Brian J F Wong Journal: Laryngoscope Date: 2015-03-16 Impact factor: 3.325
Authors: Andrew E Heidari; Ellen M Hong; Asher Park; Tiffany T Pham; Earl Steward; Lily Y Chen; Yueqiao Qu; Brandyn S Dunn; Soo H Seo; Urja Patel; Katelyn Dilley; Amir A Hakimi; Adeela Syed; Sehwan Kim; Michael G Hill; Joon S You; Brian J F Wong Journal: Lasers Surg Med Date: 2021-08-19 Impact factor: 4.025
Authors: William W Thomas; Robert M Brody; Abdullah D Alotaibi; Emilie C Rabut; Noam A Cohen; Robert Lyman; Milos Kovacevic; Oren Friedman; George R Dodge Journal: JAMA Facial Plast Surg Date: 2019-09-01 Impact factor: 4.611
Authors: Dana M Hutchison; Amir A Hakimi; Avin Wijayaweera; Soohong Seo; Ellen M Hong; Tiffany T Pham; Melissa Bircan; Ryan Sivoraphonh; Brandyn Dunn; Mark R Kobayashi; Sehwan Kim; Brian Jf Wong Journal: Scars Burn Heal Date: 2021-03-16
Authors: Katelyn K Dilley; Pamela A Borden; Yueqiao Qu; Andrew E Heidari; Karthik R Prasad; Yan Li; Chung Ho Sun; Zhongping Chen; Sehwan Kim; Michael G Hill; Brian J F Wong Journal: Transl Vis Sci Technol Date: 2022-01-03 Impact factor: 3.283