BACKGROUND: Fluid therapy may be one of the most controversial topics in perioperative management. However, data concerning the influence of perioperative fluid administration on complications after pancreaticoduodenectomy are sparse. METHODS: A group of 147 patients underwent pancreaticoduodenectomy for benign or malignant pathology of the pancreas or the periampullary region between 2005 and 2009. Clinical data, overall morbidity, and long-term outcomes were recorded. RESULTS: We categorized the patients into two groups according to intraoperative fluid volume administration: a low fluid volume group (LFVG, <8.2 ml kg(-1) hr(-1), n = 90) group, and a high fluid volume group (HFVG, ≥8.2 ml kg(-1) hr(-1), n = 57). In terms of colloid administration, the high fluid volume group received significantly more colloid both during the intraoperative period and 0-12 hr after surgery (p < .001 and p < .007, respectively). Pancreatic fistula rates were significantly greater in the high fluid volume group (p = .035). However, the long-term survival rate was not different between the two groups. CONCLUSIONS: High intraoperative fluid volume administration is associated with an increased incidence of pancreatic fistulas after pancreaticoduodenectomy.
BACKGROUND: Fluid therapy may be one of the most controversial topics in perioperative management. However, data concerning the influence of perioperative fluid administration on complications after pancreaticoduodenectomy are sparse. METHODS: A group of 147 patients underwent pancreaticoduodenectomy for benign or malignant pathology of the pancreas or the periampullary region between 2005 and 2009. Clinical data, overall morbidity, and long-term outcomes were recorded. RESULTS: We categorized the patients into two groups according to intraoperative fluid volume administration: a low fluid volume group (LFVG, <8.2 ml kg(-1) hr(-1), n = 90) group, and a high fluid volume group (HFVG, ≥8.2 ml kg(-1) hr(-1), n = 57). In terms of colloid administration, the high fluid volume group received significantly more colloid both during the intraoperative period and 0-12 hr after surgery (p < .001 and p < .007, respectively). Pancreatic fistula rates were significantly greater in the high fluid volume group (p = .035). However, the long-term survival rate was not different between the two groups. CONCLUSIONS: High intraoperative fluid volume administration is associated with an increased incidence of pancreatic fistulas after pancreaticoduodenectomy.
Authors: Mikaela L Garland; Hamish S Mace; Andrew D MacCormick; Stuart A McCluskey; Nicholas J Lightfoot Journal: J Gastrointest Surg Date: 2019-01-22 Impact factor: 3.452
Authors: Brian P Chen; Marian Chen; Sean Bennett; Kristina Lemon; Kimberly A Bertens; Fady K Balaa; Guillaume Martel Journal: World J Surg Date: 2018-09 Impact factor: 3.352
Authors: Leah K Winer; Vikrom K Dhar; Koffi Wima; Tiffany C Lee; Mackenzie C Morris; Shimul A Shah; Syed A Ahmad; Sameer H Patel Journal: J Gastrointest Surg Date: 2018-06-04 Impact factor: 3.452
Authors: Christopher W Mangieri; Michael Kuncewitch; Brett Fowler; Richard A Erali; Omeed Moaven; Perry Shen; Clancy J Clark Journal: J Surg Oncol Date: 2020-07-02 Impact factor: 3.454