Literature DB >> 2466515

Paradoxical reversion of the inhibitory effects of dihydropyridine enantiomers on the calcium current in frog heart by CGP 28861.

A Filippov1, E Kobrinsky, V Porotikov, M Saxon.   

Abstract

A dihydropyridine CGP 28861 (5 x 10(-6) M) did not change slow inward Ca current as measured by the double sucrose gap method in frog atrial fibres but decreased the agonist effects of Bay K 8644, CGP 28392, (+)-(S)-202-791 and the antagonist effects of nifedipine and (+)-(PN)-200-110. Paradoxically, the weak antagonists (-)-(R)-202-791, (-)-(PN)-200-110 and (+)-Bay K 8644 increased Ca-current after washout of CGP 28861. These data suggest that CGP 28861 can convert the dihydropyridine Ca-channel receptor from an antagonistic site into an agonistic one.

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Year:  1989        PMID： 2466515      PMCID： PMC1854372          DOI： 10.1111/j.1476-5381.1989.tb11808.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  Profile of the oppositely acting enantiomers of the dihydropyridine 202-791 in cardiac preparations: receptor binding, electrophysiological, and pharmacological studies.

Authors:  J S Williams; I L Grupp; G Grupp; P L Vaghy; L Dumont; A Schwartz; A Yatani; S Hamilton; A M Brown
Journal:  Biochem Biophys Res Commun       Date:  1985-08-30       Impact factor: 3.575

2.  The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels.

Authors:  G Franckowiak; M Bechem; M Schramm; G Thomas
Journal:  Eur J Pharmacol       Date:  1985-08-15       Impact factor: 4.432

3.  Activation of a G protein promotes agonist responses to calcium channel ligands.

Authors:  R H Scott; A C Dolphin
Journal:  Nature       Date:  1987 Dec 24-31       Impact factor: 49.962

4.  Enhancement of calcium influx in human platelets by CGP 28392, a novel dihydropyridine.

Authors:  P Erne; E Bürgisser; F R Bühler; B Dubach; H Kühnis; M Meier; H Rogg
Journal:  Biochem Biophys Res Commun       Date:  1984-02-14       Impact factor: 3.575

5.  Studies on Ca channels in intact cardiac cells: voltage-dependent effects and cooperative interactions of dihydropyridine enantiomers.

Authors:  S Kokubun; B Prod'hom; C Becker; H Porzig; H Reuter
Journal:  Mol Pharmacol       Date:  1986-12       Impact factor: 4.436

6.  Dual effects of dihydropyridines on whole cell and unitary calcium currents in single ventricular cells of guinea-pig.

Authors:  A M Brown; D L Kunze; A Yatani
Journal:  J Physiol       Date:  1986-10       Impact factor: 5.182
  6 in total
  1 in total

1.  4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action.

Authors:  Ilona Domracheva; Iveta Kanepe-Lapsa; Reinis Vilskersts; Imanta Bruvere; Egils Bisenieks; Astrida Velena; Baiba Turovska; Gunars Duburs
Journal:  Oxid Med Cell Longev       Date:  2020-03-27       Impact factor: 6.543
  1 in total

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