Literature DB >> 6322768

Enhancement of calcium influx in human platelets by CGP 28392, a novel dihydropyridine.

P Erne, E Bürgisser, F R Bühler, B Dubach, H Kühnis, M Meier, H Rogg.   

Abstract

CGP 28392, a novel compound structurally related to the dihydropyridine Ca2+-entry blockers, causes a dose-dependent increase in intracellular free Ca2+ in human platelets, as measured with the Quin-2 Ca2+ indicator, with a semimaximal effective concentration of 2.2 X 10(-7) M. This effect occurs in a concentration range in which CGP 28392 competes for specific [3H]nitrendipine binding in guinea pig heart membranes. It can be inhibited by nitrendipine. The data presented furnish direct evidence of the Ca2+-entry-stimulating properties of CGP 28392 and indicate the presence of dihydropyridine-susceptible structures in human platelets.

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Year:  1984        PMID： 6322768     DOI： 10.1016/0006-291x(84)91471-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  12 in total

1.  RS 30026: a potent and effective calcium channel agonist.

Authors:  L Patmore; G P Duncan; B Clarke; A J Anderson; R Greenhouse; J R Pfister
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739

2.  The dihydropyridine derivative, Bay K 8644, enhances insulin secretion by isolated pancreatic islets.

Authors:  U Panten; S Zielmann; M T Schrader; S Lenzen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-01       Impact factor: 3.000

3.  Different insulin-secretory responses to calcium-channel blockers in islets of lean and obese (ob/ob) mice.

Authors:  M A Black; L A Fournier; H M Heick; N Bégin-Heick
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

4.  Paradoxical reversion of the inhibitory effects of dihydropyridine enantiomers on the calcium current in frog heart by CGP 28861.

Authors:  A Filippov; E Kobrinsky; V Porotikov; M Saxon
Journal:  Br J Pharmacol       Date:  1989-02       Impact factor: 8.739

5.  Effects of calcium channel antagonists and facilitators on beating of primary cultures of embryonic chick heart cells.

Authors:  L Patmore; G P Duncan
Journal:  Br J Pharmacol       Date:  1988-11       Impact factor: 8.739

6.  Ca-agonists: a new class of inotropic drugs.

Authors:  M Bechem; R Gross; S Hebisch; M Schramm
Journal:  Basic Res Cardiol       Date:  1989       Impact factor: 17.165

7.  The behavioral effects of the calcium agonist Bay K 8644 in the mouse: antagonism by the calcium antagonist nifedipine.

Authors:  G T Bolger; B A Weissman; P Skolnick
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-02       Impact factor: 3.000

8.  Biphasic inotropic effects of a Ca2+ channel activator CGP28392 in rat myocardium: possible relation to intracellular Ca2+ release.

Authors:  E Kobrinsky; M Saxon
Journal:  Br J Pharmacol       Date:  1987-11       Impact factor: 8.739

9.  Effects of the calcium-channel agonist CGP 28392 on insulin secretion from isolated rat islets of Langerhans.

Authors:  N G Morgan; C D Short; G M Rumford; W Montague
Journal:  Biochem J       Date:  1985-11-01       Impact factor: 3.857

10.  Stimulation of insulin release by an organic calcium agonist.

Authors:  W J Malaisse; P C Mathias
Journal:  Diabetologia       Date:  1985-03       Impact factor: 10.122
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