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Literature DB >> 2412855

The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels.

G Franckowiak, M Bechem, M Schramm, G Thomas.

Abstract

The optical isomers of the 1,4-dihydropyridine BAY K 8644 were studied in isolated rabbit aorta and heart preparations. The (-)-enantiomer has the known vasoconstricting and positive inotropic properties of the Ca agonistic compound. In contrast, its antipode shows at about 10-50 times higher concentrations the vasodilating and negative inotropic effects of Ca antagonistic drugs. It is concluded that neither simple chemical nor physical actions can be responsible for the opposite effects of Ca antagonistic and Ca agonistic dihydropyridines.

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Year: 1985 PMID： 2412855 DOI： 10.1016/0014-2999(85)90631-4

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

54 in total

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Journal: Br J Pharmacol Date: 2001-03 Impact factor: 8.739

2. The effects of chronic treatment with the dihydropyridine, Bay K 8644, on hyperexcitability due to ethanol withdrawal, in vivo and in vitro.

Authors: M A Whittington; A R Butterworth; S J Dolin; T L Patch; H J Little
Journal: Br J Pharmacol Date: 1992-02 Impact factor: 8.739

3. Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment.

Authors: Yama A Abassi; Biao Xi; Nan Li; Wei Ouyang; Alexander Seiler; Manfred Watzele; Ralf Kettenhofen; Heribert Bohlen; Andreas Ehlich; Eugen Kolossov; Xiaobo Wang; Xiao Xu
Journal: Br J Pharmacol Date: 2012-03 Impact factor: 8.739

10. (+)-S-12967 and (-)-S-12968: 1,4-dihydropyridine stereoisomers with calcium channel agonistic and antagonistic properties in rat resistance arteries.

Authors: D Prieto; M J Mulvany; N C Nyborg
Journal: Br J Pharmacol Date: 1991-07 Impact factor: 8.739

The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels.

1. Mechanism of CGRP-induced relaxation in rat intramural coronary arteries.

2. The effects of chronic treatment with the dihydropyridine, Bay K 8644, on hyperexcitability due to ethanol withdrawal, in vivo and in vitro.

3. Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment.

4. RS 30026: a potent and effective calcium channel agonist.

5. Effects of calcium channel modulators on the proliferation of mouse spleen lymphocytes in vitro.

6. Molecular level model for the agonist/antagonist selectivity of the 1,4-dihydropyridine calcium channel receptor.

7. Voltage-dependent effects of YC-170, a dihydropyridine calcium channel modulator, in cardiovascular tissues.

8. Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence.

9. Endothelin-induced increases in vascular smooth muscle Ca2+ do not depend on dihydropyridine-sensitive Ca2+ channels.

10. (+)-S-12967 and (-)-S-12968: 1,4-dihydropyridine stereoisomers with calcium channel agonistic and antagonistic properties in rat resistance arteries.