Adjuvant and neoadjuvant vincristine, bleomycin, and methotrexate for inguinal metastases from squamous cell carcinoma of the penis.

In a pilot study 12 patients with radically resected inguinal lymph node metastases from carcinoma of the penis and 5 patients with fixed inguinal nodes were treated with 12 weekly courses of vincristine, bleomycin and methotrexate (VBM). Only 1 of the 12 cases treated with adjuvant VBM relapsed after a median follow-up period of 42 months (range 18-102 months). Three partial responders to neoadjuvant VBM could have radical lymphadenectomy and they are alive disease-free 20, 27, 72 months after surgery. Two minimal responders could not have radical surgery and they died of the disease within one year.