BACKGROUND: Kawasaki disease (KD) is an acute, self-limited vasculitis in infants and young children. Interleukin-10 (IL-10) is a potent cytokine that exerts pleiotropic effects on immunoregulation and inflammation. Elevated IL-10 serum levels have been reported in the KD patients. METHODS: In this study, we investigated whether IL-10 genetic polymorphisms contribute to coronary artery aneurysm (CAA) development among KD patients in Taiwan. A total of 58 KD patients with CAA and 277 unrelated healthy children matched for sex and age were enrolled for this study. RESULTS: Higher G allele frequencies of IL-10 at -1082 position were observed in KD patients with CAA compared to the controls (P = 0.016, OR: 2.86, 95% CI, 1.17-6.98). In addition, higher IL-10 GCC haplotype frequencies were also observed in KD patients with CAA (P = 0.016, OR: 2.85, 95% CI, 1.17-6.98). CONCLUSION: Our data support the possibility that IL-10 gene polymorphisms may be related with CAA development of KD in Taiwanese population.
BACKGROUND:Kawasaki disease (KD) is an acute, self-limited vasculitis in infants and young children. Interleukin-10 (IL-10) is a potent cytokine that exerts pleiotropic effects on immunoregulation and inflammation. Elevated IL-10 serum levels have been reported in the KDpatients. METHODS: In this study, we investigated whether IL-10 genetic polymorphisms contribute to coronary artery aneurysm (CAA) development among KDpatients in Taiwan. A total of 58 KDpatients with CAA and 277 unrelated healthy children matched for sex and age were enrolled for this study. RESULTS: Higher G allele frequencies of IL-10 at -1082 position were observed in KDpatients with CAA compared to the controls (P = 0.016, OR: 2.86, 95% CI, 1.17-6.98). In addition, higher IL-10 GCC haplotype frequencies were also observed in KDpatients with CAA (P = 0.016, OR: 2.85, 95% CI, 1.17-6.98). CONCLUSION: Our data support the possibility that IL-10 gene polymorphisms may be related with CAA development of KD in Taiwanese population.
Authors: T Origuchi; E Kawasaki; A Ide; M Kamachi; F Tanaka; H Ida; A Kawakami; K Migita; K Eguchi Journal: Ann Rheum Dis Date: 2003-11 Impact factor: 19.103
Authors: Jane W Newburger; Masato Takahashi; Michael A Gerber; Michael H Gewitz; Lloyd Y Tani; Jane C Burns; Stanford T Shulman; Ann F Bolger; Patricia Ferrieri; Robert S Baltimore; Walter R Wilson; Larry M Baddour; Matthew E Levison; Thomas J Pallasch; Donald A Falace; Kathryn A Taubert Journal: Pediatrics Date: 2004-12 Impact factor: 7.124
Authors: H Kato; T Sugimura; T Akagi; N Sato; K Hashino; Y Maeno; T Kazue; G Eto; R Yamakawa Journal: Circulation Date: 1996-09-15 Impact factor: 29.690