Literature DB >> 9043871

An investigation of polymorphism in the interleukin-10 gene promoter.

D M Turner1, D M Williams, D Sankaran, M Lazarus, P J Sinnott, I V Hutchinson.   

Abstract

Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.

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Year:  1997        PMID： 9043871     DOI： 10.1111/j.1365-2370.1997.tb00001.x

Source DB:  PubMed          Journal:  Eur J Immunogenet        ISSN： 0960-7420


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