Literature DB >> 24656077

Sensitivity enhancement in solution NMR: emerging ideas and new frontiers.

Jung Ho Lee1, Yusuke Okuno1, Silvia Cavagnero2.   

Abstract

Modern NMR spectroscopy has reached an unprecedented level of sophistication in the determination of biomolecular structure and dynamics at atomic resolution in liquids. However, the sensitivity of this technique is still too low to solve a variety of cutting-edge biological problems in solution, especially those that involve viscous samples, very large biomolecules or aggregation-prone systems that need to be kept at low concentration. Despite the challenges, a variety of efforts have been carried out over the years to increase sensitivity of NMR spectroscopy in liquids. This review discusses basic concepts, recent developments and future opportunities in this exciting area of research.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Dissolution DNP; Fast NMR; Hyperpolarization; NMR sensitivity; Overhauser DNP; PHIP; Photo-CIDNP; SEOP

Mesh：

Substances：

Year:  2014        PMID： 24656077      PMCID： PMC3967054          DOI： 10.1016/j.jmr.2014.01.005

Source DB:  PubMed          Journal:  J Magn Reson        ISSN： 1090-7807            Impact factor:   2.229


  96 in total

1.  Functionalized xenon as a biosensor.

Authors:  M M Spence; S M Rubin; I E Dimitrov; E J Ruiz; D E Wemmer; A Pines; S Q Yao; F Tian; P G Schultz
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-04       Impact factor: 11.205

Review 2.  Nuclear magnetic resonance of laser-polarized noble gases in molecules, materials, and organisms.

Authors:  Boyd M Goodson
Journal:  J Magn Reson       Date:  2002-04       Impact factor: 2.229

3.  HIFI-C: a robust and fast method for determining NMR couplings from adaptive 3D to 2D projections.

Authors:  Gabriel Cornilescu; Arash Bahrami; Marco Tonelli; John L Markley; Hamid R Eghbalnia
Journal:  J Biomol NMR       Date:  2007-07-04       Impact factor: 2.835

4.  Real-time monitoring of chemical transformations by ultrafast 2D NMR spectroscopy.

Authors:  Maayan Gal; Mor Mishkovsky; Lucio Frydman
Journal:  J Am Chem Soc       Date:  2006-01-25       Impact factor: 15.419

5.  Long-lived states to sustain hyperpolarized magnetization.

Authors:  P R Vasos; A Comment; R Sarkar; P Ahuja; S Jannin; J-P Ansermet; J A Konter; P Hautle; B van den Brandt; G Bodenhausen
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-19       Impact factor: 11.205

6.  Liquid state DNP using a 260 GHz high power gyrotron.

Authors:  Vasyl Denysenkov; Mark J Prandolini; Marat Gafurov; Deniz Sezer; Burkhard Endeward; Thomas F Prisner
Journal:  Phys Chem Chem Phys       Date:  2010-05-11       Impact factor: 3.676

7.  In situ temperature jump high-frequency dynamic nuclear polarization experiments: enhanced sensitivity in liquid-state NMR spectroscopy.

Authors:  Chan-Gyu Joo; Kan-Nian Hu; Jeffrey A Bryant; Robert G Griffin
Journal:  J Am Chem Soc       Date:  2006-07-26       Impact factor: 15.419

8.  Poisson-gap sampling and forward maximum entropy reconstruction for enhancing the resolution and sensitivity of protein NMR data.

Authors:  Sven G Hyberts; Koh Takeuchi; Gerhard Wagner
Journal:  J Am Chem Soc       Date:  2010-02-24       Impact factor: 15.419

9.  HyperSPASM NMR: a new approach to single-shot 2D correlations on DNP-enhanced samples.

Authors:  Kevin J Donovan; Lucio Frydman
Journal:  J Magn Reson       Date:  2012-10-29       Impact factor: 2.229

10.  EPIC- and CHANCE-HSQC: two 15N-photo-CIDNP-enhanced pulse sequences for the sensitive detection of solvent-exposed tryptophan.

Authors:  Ashok Sekhar; Silvia Cavagnero
Journal:  J Magn Reson       Date:  2009-07-04       Impact factor: 2.229
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  36 in total

1.  Laser- and cryogenic probe-assisted NMR enables hypersensitive analysis of biomolecules at submicromolar concentration.

Authors:  Yusuke Okuno; Miranda F Mecha; Hanming Yang; Lingchao Zhu; Charles G Fry; Silvia Cavagnero
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-29       Impact factor: 11.205

Review 2.  The role of small-angle scattering in structure-based screening applications.

Authors:  Po-Chia Chen; Janosch Hennig
Journal:  Biophys Rev       Date:  2018-10-10

Review 3.  Probing carbohydrate metabolism using hyperpolarized 13 C-labeled molecules.

Authors:  Jaspal Singh; Eul Hyun Suh; Gaurav Sharma; Chalermchai Khemtong; A Dean Sherry; Zoltan Kovacs
Journal:  NMR Biomed       Date:  2018-11-26       Impact factor: 4.044

4.  Non-Uniform Sampling in NMR Spectroscopy and the Preservation of Spectral Knowledge in the Time and Frequency Domains.

Authors:  Manpreet Kaur; Callie M Lewis; Aaron Chronister; Gabriel S Phun; Leonard J Mueller
Journal:  J Phys Chem A       Date:  2020-06-18       Impact factor: 2.781

5.  Improved sensitivity of laser-enhanced 1Hα-13Cα-correlation via suppression of Cα-C' scalar-coupling evolution.

Authors:  Hanming Yang; Silvia Cavagnero
Journal:  J Magn Reson       Date:  2019-08-13       Impact factor: 2.229

6.  Effect of heavy atoms on photochemically induced dynamic nuclear polarization in liquids.

Authors:  Yusuke Okuno; Silvia Cavagnero
Journal:  J Magn Reson       Date:  2017-12-05       Impact factor: 2.229

7.  Application of 15N2-Diazirines as a Versatile Platform for Hyperpolarization of Biological Molecules by d-DNP.

Authors:  Hyejin Park; Guannan Zhang; Junu Bae; Thomas Theis; Warren S Warren; Qiu Wang
Journal:  Bioconjug Chem       Date:  2020-02-14       Impact factor: 4.774

8.  Rational Design of [13 C,D14 ]Tert-butylbenzene as a Scaffold Structure for Designing Long-lived Hyperpolarized 13 C Probes.

Authors:  Yuki Imakura; Hiroshi Nonaka; Yoichi Takakusagi; Kazuhiro Ichikawa; Nesmine R Maptue; Alexander M Funk; Chalermchai Khemtong; Shinsuke Sando
Journal:  Chem Asian J       Date:  2018-01-16

9.  Imaging of Biomolecular NMR Signals Amplified by Reversible Exchange with Parahydrogen Inside an MRI Scanner.

Authors:  Kirill V Kovtunov; Bryce E Kidd; Oleg G Salnikov; Liana B Bales; Max E Gemeinhardt; Jonathan Gesiorski; Roman V Shchepin; Eduard Y Chekmenev; Boyd M Goodson; Igor V Koptyug
Journal:  J Phys Chem C Nanomater Interfaces       Date:  2017-11-01       Impact factor: 4.126

10.  Fluorescein: A Photo-CIDNP Sensitizer Enabling Hypersensitive NMR Data Collection in Liquids at Low Micromolar Concentration.

Authors:  Yusuke Okuno; Silvia Cavagnero
Journal:  J Phys Chem B       Date:  2016-01-22       Impact factor: 2.991
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