Lucy Binda John-Africa1, Tijani Adeniyi Yahaya1, Christianah Yetunde Isimi2. 1. Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu, Abuja. 2. Department of Raw Materials Research and Pharmaceutical Technology, National Institute for Pharmaceutical Research and Development, Idu, Abuja.
Abstract
BACKGROUND: There are strong beliefs in the efficacy of traditional medical systems worldwide. Many herbs have been acclaimed to possess antiulcer effects and could be unexplored sources of new lead compounds. Sida corymbosa R. E. Fries (Malvaceae) is used in Northern Nigeria to treat ulcers and wounds. This work aimed to investigate the usefulness of Sida corymbosa in treatments of stomach ulcers and wounds in traditional medicine. MATERIALS AND METHODS: Effect of the aqueous extract was determined on gastric ulceration, rate of wound healing and inflammation using ethanol-induced and diclofenac-induced ulceration, wound excision model and albumin-induced inflammation respectively in rats. RESULTS: The study demonstrated the anti-ulcer activity of Sida corymbosa as the extract (250, 500 and 1000 mg/kg) showed a dose-dependent, significant (P<0.05) reduction of ulcer indices against gastric ulcers induced by both ethanol and diclofenac. Topical application of a formulation prepared with the extract of Sida corymbosa on surgically created incisions produced an increase in the rate of healing of the wounds. The extract of Sida corymbosa exhibited a significant (P < 0.05), dose-related decrease in inflammation induced by fresh egg albumin. This study showed that Sida corymbosa has constituents with the ability to reduce the severity of haemorrhagic gastric lesions, promote wound healing and reduce inflammation. These actions may be attributed to any one of the active constituents or as a result of synergistic effects of these phytoconstituents. CONCLUSION: This study validates the use of the plant in traditional medicine for the treatment of stomach ulcers and wounds.
BACKGROUND: There are strong beliefs in the efficacy of traditional medical systems worldwide. Many herbs have been acclaimed to possess antiulcer effects and could be unexplored sources of new lead compounds. Sida corymbosa R. E. Fries (Malvaceae) is used in Northern Nigeria to treat ulcers and wounds. This work aimed to investigate the usefulness of Sida corymbosa in treatments of stomach ulcers and wounds in traditional medicine. MATERIALS AND METHODS: Effect of the aqueous extract was determined on gastric ulceration, rate of wound healing and inflammation using ethanol-induced and diclofenac-induced ulceration, wound excision model and albumin-induced inflammation respectively in rats. RESULTS: The study demonstrated the anti-ulcer activity of Sida corymbosa as the extract (250, 500 and 1000 mg/kg) showed a dose-dependent, significant (P<0.05) reduction of ulcer indices against gastric ulcers induced by both ethanol and diclofenac. Topical application of a formulation prepared with the extract of Sida corymbosa on surgically created incisions produced an increase in the rate of healing of the wounds. The extract of Sida corymbosa exhibited a significant (P < 0.05), dose-related decrease in inflammation induced by fresh egg albumin. This study showed that Sida corymbosa has constituents with the ability to reduce the severity of haemorrhagic gastric lesions, promote wound healing and reduce inflammation. These actions may be attributed to any one of the active constituents or as a result of synergistic effects of these phytoconstituents. CONCLUSION: This study validates the use of the plant in traditional medicine for the treatment of stomach ulcers and wounds.
Authors: Vanja M Tadić; Silva Dobrić; Goran M Marković; Sofija M Dordević; Ivana A Arsić; Nebojsa R Menković; Tanja Stević Journal: J Agric Food Chem Date: 2008-08-13 Impact factor: 5.279
Authors: Heloina de Sousa Falcão; Jacqueline Alves Leite; José Maria Barbosa-Filho; Petrônio Filgueiras de Athayde-Filho; Maria Célia de Oliveira Chaves; Marcelo Dantas Moura; Anderson Luiz Ferreira; Ana Beatriz Albino de Almeida; Alba Regina Monteiro Souza-Brito; Margareth de Fátima Formiga Melo Diniz; Leônia Maria Batista Journal: Molecules Date: 2008-12-17 Impact factor: 4.411