Literature DB >> 10996281

Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats.

P A Nwafor1, F K Okwuasaba, L G Binda.   

Abstract

The effect of methanolic extract of Asparagus pubescens root on experimentally-induced diarrhoea and ulceration was investigated in rats. The extract (500-1500 mg/kg) dose-dependently, reduced significantly the intestinal propulsive movement, castor oil-induced diarrhoea and intestinal fluid accumulation. Yohimbine an alpha(2)-adrenoceptor blocker attenuated the antidiarrhoeal effect of the extract. The extract also reduced the ulcer indices induced by indomethacin and ethanol in a dose-related manner. The results indicate that its antidiarrhoeal and antiulcerogenic effects might in part be due to its alpha(2)-adrenoceptor stimulation and its active constituents respectively.

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Year:  2000        PMID： 10996281     DOI： 10.1016/s0378-8741(00)00261-0

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  23 in total

1.  Anti-ulcer and wound healing activities of Sida corymbosa in rats.

Authors:  Lucy Binda John-Africa; Tijani Adeniyi Yahaya; Christianah Yetunde Isimi
Journal:  Afr J Tradit Complement Altern Med       Date:  2013-11-02

2.  Evaluation of the gastroprotective activity of the extracts, fractions, and pure compounds obtained from aerial parts of Rubus imperialis in different experimental models.

Authors:  Priscila Elisabeth Berté; Jhonny da Silva Lopes; Nicole Garbin Comandulli; Daniele Wolff Rangel; Franco Delle Monache; Valdir Cechinel Filho; Rivaldo Niero; Sergio Faloni de Andrade
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2014-01-09       Impact factor: 3.000

3.  Antiulcerogenic activity of ethanolic leaf extract of Lasianthera africana.

Authors:  Jude E Okokon; Bassey S Antia; Emem E Umoh
Journal:  Afr J Tradit Complement Altern Med       Date:  2009-03-07

4.  Ficus platyphylla promotes fertility in female Rattus norvegicus Wistar strain: a preliminary study.

Authors:  Chinenye J Ugwah-Oguejiofor; Shaibu O Bello; Raymond U Okolo; Emmanuel U Etuk; Michael O Ugwah; Vincent U Igbokwe
Journal:  Reprod Biol Endocrinol       Date:  2011-11-02       Impact factor: 5.211

5.  Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models.

Authors:  José Roberto Santin; Marivane Lemos; Luiz Carlos Klein-Júnior; Isabel Daufenback Machado; Philipe Costa; Ana Paula de Oliveira; Crislaine Tilia; Juliana Paula de Souza; João Paulo Barreto de Sousa; Jairo Kenupp Bastos; Sérgio Faloni de Andrade
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-12-08       Impact factor: 3.000

6.  Constituents of leaves from Bauhinia curvula Benth. exert gastroprotective activity in rodents: role of quercitrin and kaempferol.

Authors:  Ana Paula Beber; Priscila de Souza; Thaise Boeing; Lincon Bordignon Somensi; Luísa Nathália Bolda Mariano; Benhur Judah Cury; Ligia Moura Burci; Cristiane Bezerra da Silva; Euclésio Simionatto; Sérgio Faloni de Andrade; Luísa Mota da Silva
Journal:  Inflammopharmacology       Date:  2017-02-07       Impact factor: 4.473

7.  Protective effect of leaves of Raphinus sativus Linn on experimentally induced gastric ulcers in rats.

Authors:  V C Devaraj; B Gopala Krishna; G L Viswanatha; V Satya Prasad; S N Vinay Babu
Journal:  Saudi Pharm J       Date:  2011-03-11       Impact factor: 4.330

8.  Gastroprotective Activities of Ethanol Extract of Black Rice Bran (Oryza sativa L.) in Rats.

Authors:  Peerachit Tonchaiyaphum; Warangkana Arpornchayanon; Parirat Khonsung; Natthakarn Chiranthanut; Pornsiri Pitchakarn; Puongtip Kunanusorn
Journal:  Molecules       Date:  2021-06-22       Impact factor: 4.411

9.  Protective Effects of Anwulignan against HCl/Ethanol-Induced Acute Gastric Ulcer in Mice.

Authors:  Jiawei Liu; Huijiao Lin; Liwei Yuan; Dan Wang; Chunmei Wang; Jinghui Sun; Chengyi Zhang; Jianguang Chen; He Li; Shu Jing
Journal:  Evid Based Complement Alternat Med       Date:  2021-07-14       Impact factor: 2.629

10.  Evaluation of Antiulcer Properties of Ethanolic and Hot Aqueous Stem Extracts of Synclisia scabrida on Experimentally Induced Ulcer Models in Albino Mice.

Authors:  Tc Onwudiwe; Po Ughachukwu; Pc Unekwe; Jo Ogamba
Journal:  Ann Med Health Sci Res       Date:  2012-07
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