Literature DB >> 2464829

Iloprost-induced translocation of a 23-kDa protein that is recognized by a Gs alpha antiserum.

L Molina Y Vedia1, E G Lapetina.   

Abstract

We have observed that iloprost, a prostacyclin analog, causes the translocation of a 23-kDa protein from the membrane to the cytosol of human platelets. This 23-kDa protein is recognized by a Gs alpha (alpha subunit of stimulatory guanine nucleotide binding regulatory protein) antiserum but is not ADP-ribosylated by cholera toxin. The translocation of the Gs alpha-related protein might be an important part of the complex chain of events resulting in agonist-induced desensitization.

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Year:  1989        PMID： 2464829      PMCID： PMC286579          DOI： 10.1073/pnas.86.3.868

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  12 in total

1.  Desensitization of prostacyclin responsiveness in platelets. Apparent differences in the mechanism in vitro or in vivo.

Authors:  J MacDermot
Journal:  Biochem Pharmacol       Date:  1986-08-15       Impact factor: 5.858

Review 2.  G proteins: transducers of receptor-generated signals.

Authors:  A G Gilman
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

3.  Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins.

Authors:  S M Mumby; R A Kahn; D R Manning; A G Gilman
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

4.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

5.  Platelet cytosolic 44-kDa protein is a substrate of cholera toxin-induced ADP-ribosylation and is not recognized by antisera against the alpha subunit of the stimulatory guanine nucleotide-binding regulatory protein.

Authors:  L M Molina y Vedia; B R Reep; E G Lapetina
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

6.  Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

Authors:  P Goldsmith; P Gierschik; G Milligan; C G Unson; R Vinitsky; H L Malech; A M Spiegel
Journal:  J Biol Chem       Date:  1987-10-25       Impact factor: 5.157

7.  Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.

Authors:  J E Buss; S M Mumby; P J Casey; A G Gilman; B M Sefton
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

8.  Modulation of human platelet adenylate cyclase by prostacyclin (PGX).

Authors:  R R Gorman; S Bunting; O V Miller
Journal:  Prostaglandins       Date:  1977-03

9.  Prostacyclin analogues reduce ADP-ribosylation of the alpha-subunit of the regulatory Gs-protein and diminish adenosine (A2) responsiveness of platelets.

Authors:  R J Edwards; J MacDermot; A J Wilkins
Journal:  Br J Pharmacol       Date:  1987-03       Impact factor: 8.739

10.  Prevention of degradation of human polymorphonuclear leukocyte proteins by diisopropylfluorophosphate.

Authors:  P C Amrein; T P Stossel
Journal:  Blood       Date:  1980-09       Impact factor: 22.113
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  4 in total

1.  Inhibition of subunit dissociation and release of the stimulatory G-protein, Gs, by beta gamma-subunits and somatostatin in S49 lymphoma cell membranes.

Authors:  L A Ransnäs; D Leiber; P A Insel
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

2.  The effect of inhibitors of platelet aggregation on the metabolism of platelet-activating factor (PAF) in washed rabbit platelets.

Authors:  C O'Neill; A J Ammit; R Korth; S Fleming; X Wells
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

3.  Subcellular distribution of alpha 2-adrenergic receptors, pertussis-toxin substrate and adenylate cyclase in human platelets.

Authors:  M A Zamorski; J C Ferraro; R R Neubig
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

4.  The effect of iloprost on the ADP-ribosylation of Gs alpha (the alpha-subunit of Gs).

Authors:  L Molina y Vedia; R D Nolan; E G Lapetina
Journal:  Biochem J       Date:  1989-08-01       Impact factor: 3.857
  4 in total

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