| Literature DB >> 191876 |
R R Gorman, S Bunting, O V Miller.
Abstract
Prostacyclin (PGX) (57)-9-deoxy-6,9alpha-epoxy-delta5-PGF1alpha has been found to be a potent stimulator of cAMP accumulation in platelets than PGE1. The prostacyclin stimulation of platelet cAMP accumulation can be antagonized by the prostaglandin endoperoxide PGH2, and a PGH2-induced platelet aggregation is antagonized by prostacyclin. A model of platelet homeostasis is proposed that suggests platelet aggregation is controlled by a balance between the adenylate cyclase stimulating activity of prostacyclin, and the cAMP lowering activity of PGH2.Entities:
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Year: 1977 PMID： 191876 DOI： 10.1016/0090-6980(77)90018-1
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980