Literature DB >> 3079909

Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins.

S M Mumby, R A Kahn, D R Manning, A G Gilman.   

Abstract

Antisera were raised against purified subunits of regulatory GTP-binding proteins (G proteins) and against synthetic peptides that correspond to defined regions of G proteins. Peptide antisera were generated that recognized all alpha or all beta subunits from Gs, Gi, Go, and transducin; others recognized only Gs alpha or Go alpha. Such cross-reaction or complete specificity for a given alpha subunit was not obtained when purified subunits were injected. Peptide antisera were used to identify G protein subunits in selected tissue membrane preparations by immunoblots.

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Year:  1986        PMID： 3079909      PMCID： PMC322838          DOI： 10.1073/pnas.83.2.265

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  Characterization of transducin from bovine retinal rod outer segments. II. Evidence for distinct binding sites and conformational changes revealed by limited proteolysis with trypsin.

Authors:  B K Fung; C R Nash
Journal:  J Biol Chem       Date:  1983-09-10       Impact factor: 5.157

2.  Tapping the immunological repertoire to produce antibodies of predetermined specificity.

Authors:  R A Lerner
Journal:  Nature       Date:  1982-10-14       Impact factor: 49.962

3.  Immunogenic structure of the influenza virus hemagglutinin.

Authors:  N Green; H Alexander; A Olson; S Alexander; T M Shinnick; J G Sutcliffe; R A Lerner
Journal:  Cell       Date:  1982-03       Impact factor: 41.582

4.  G proteins and dual control of adenylate cyclase.

Authors:  A G Gilman
Journal:  Cell       Date:  1984-03       Impact factor: 41.582

5.  The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins.

Authors:  D R Manning; A G Gilman
Journal:  J Biol Chem       Date:  1983-06-10       Impact factor: 5.157

6.  Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

Authors:  G M Bokoch; T Katada; J K Northup; M Ui; A G Gilman
Journal:  J Biol Chem       Date:  1984-03-25       Impact factor: 5.157

7.  Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex.

Authors:  W J Schneider; J L Goldstein; M S Brown
Journal:  J Biol Chem       Date:  1980-12-10       Impact factor: 5.157

8.  Equilibrium calcium-calcium exchange in cardiac sarcolemmal vesicles.

Authors:  R S Slaughter; J L Sutko; J P Reeves
Journal:  J Biol Chem       Date:  1983-03-10       Impact factor: 5.157

9.  Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

Authors:  B K Fung
Journal:  J Biol Chem       Date:  1983-09-10       Impact factor: 5.157

10.  Flow of information in the light-triggered cyclic nucleotide cascade of vision.

Authors:  B K Fung; J B Hurley; L Stryer
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205
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  70 in total

1.  Vasoactive intestinal peptide receptors in rat liver after partial hepatectomy.

Authors:  L G Guijarro; A Couvineau; M S Rodriguez-Pena; M G Juarranz; N Rodriguez-Henche; E Arilla; M Laburthe; J C Prieto
Journal:  Biochem J       Date:  1992-07-15       Impact factor: 3.857

2.  Retinal rods and cones have distinct G protein beta and gamma subunits.

Authors:  Y W Peng; J D Robishaw; M A Levine; K W Yau
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

3.  Differential expression of guanine nucleotide-binding proteins enhances cAMP synthesis in regenerating rat liver.

Authors:  A M Diehl; S Q Yang; D Wolfgang; G Wand
Journal:  J Clin Invest       Date:  1992-06       Impact factor: 14.808

4.  Proximal tubular epithelial cells possess a novel 42-kilodalton guanine nucleotide-binding regulatory protein.

Authors:  J Zhou; C Sims; C H Chang; L Berti-Mattera; U Hopfer; J Douglas
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

5.  Developmental regulation of calmodulin-dependent adenylate cyclase activity in an insect endocrine gland.

Authors:  V Meller; S Sakurai; L I Gilbert
Journal:  Cell Regul       Date:  1990-09

6.  Pleiotropic phenotype of a genomic knock-in of an RGS-insensitive G184S Gnai2 allele.

Authors:  Xinyan Huang; Ying Fu; Raelene A Charbeneau; Thomas L Saunders; Douglas K Taylor; Kurt D Hankenson; Mark W Russell; Louis G D'Alecy; Richard R Neubig
Journal:  Mol Cell Biol       Date:  2006-09       Impact factor: 4.272

7.  Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes.

Authors:  K H Muntz; P C Sternweis; A G Gilman; S M Mumby
Journal:  Mol Biol Cell       Date:  1992-01       Impact factor: 4.138

8.  Pertussis toxin-sensitive G proteins are transported toward synaptic terminals by fast axonal transport.

Authors:  S S Vogel; G J Chin; J H Schwartz; T S Reese
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

9.  Cloning and expression of a widely distributed (type IV) adenylyl cyclase.

Authors:  B N Gao; A G Gilman
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

10.  Sequence of the beta-subunit of the phosphatidylinositol-specific phospholipase C-directed GTP-binding protein from squid (Loligo forbesi) photoreceptors.

Authors:  N J Ryba; J D Pottinger; J N Keen; J B Findlay
Journal:  Biochem J       Date:  1991-01-01       Impact factor: 3.857
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