Literature DB >> 24633655

The MOZ histone acetyltransferase in epigenetic signaling and disease.

Samuel Carlson1, Karen C Glass.   

Abstract

The monocytic leukemic zinc finger (MOZ) histone acetyltransferase (HAT) plays a role in acute myeloid leukemia (AML). It functions as a quaternary complex with the bromodomain PHD finger protein 1 (BRPF1), the human Esa1-associated factor 6 homolog (hEAF6), and the inhibitor of growth 5 (ING5). Each of these subunits contain chromatin reader domains that recognize specific post-translational modifications (PTMs) on histone tails, and this recognition directs the MOZ HAT complex to specific chromatin substrates. The structure and function of these epigenetic reader modules has now been elucidated, and a model describing how the cooperative action of these domains regulates HAT activity in response to the epigenetic landscape is proposed. The emerging role of epigenetic reader domains in disease, and their therapeutic potential for many types of cancer is also highlighted.
© 2014 Wiley Periodicals, Inc.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24633655      PMCID： PMC4750494          DOI： 10.1002/jcp.24617

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  43 in total

1.  Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation.

Authors:  I Kitabayashi; Y Aikawa; A Yokoyama; F Hosoda; M Nagai; N Kakazu; T Abe; M Ohki
Journal:  Leukemia       Date:  2001-01       Impact factor: 11.528

2.  Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1.

Authors:  Alessandro Vezzoli; Nicolas Bonadies; Mark D Allen; Stefan M V Freund; Clara M Santiveri; Brynn T Kvinlaug; Brian J P Huntly; Berthold Göttgens; Mark Bycroft
Journal:  Nat Struct Mol Biol       Date:  2010-04-18       Impact factor: 15.369

Review 3.  Structural insight into histone recognition by the ING PHD fingers.

Authors:  Karen S Champagne; Tatiana G Kutateladze
Journal:  Curr Drug Targets       Date:  2009-05       Impact factor: 3.465

4.  HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail.

Authors:  Nehmé Saksouk; Nikita Avvakumov; Karen S Champagne; Tiffany Hung; Yannick Doyon; Christelle Cayrou; Eric Paquet; Mukta Ullah; Anne-Julie Landry; Valérie Côté; Xiang-Jiao Yang; Or Gozani; Tatiana G Kutateladze; Jacques Côté
Journal:  Mol Cell       Date:  2009-01-30       Impact factor: 17.970

5.  Transcriptional regulation of the human MIP-1alpha promoter by RUNX1 and MOZ.

Authors:  Claire A P Bristow; Paul Shore
Journal:  Nucleic Acids Res       Date:  2003-06-01       Impact factor: 16.971

6.  Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity.

Authors:  Anne K Voss; Caitlin Collin; Mathew P Dixon; Tim Thomas
Journal:  Dev Cell       Date:  2009-11       Impact factor: 12.270

7.  The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein.

Authors:  J Borrow; V P Stanton; J M Andresen; R Becher; F G Behm; R S Chaganti; C I Civin; C Disteche; I Dubé; A M Frischauf; D Horsman; F Mitelman; S Volinia; A E Watmore; D E Housman
Journal:  Nat Genet       Date:  1996-09       Impact factor: 38.330

8.  The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors.

Authors:  Flor M Perez-Campo; Julian Borrow; Valerie Kouskoff; Georges Lacaud
Journal:  Blood       Date:  2009-03-05       Impact factor: 22.113

9.  Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

Authors:  Mukta Ullah; Nadine Pelletier; Lin Xiao; Song Ping Zhao; Kainan Wang; Cindy Degerny; Soroush Tahmasebi; Christelle Cayrou; Yannick Doyon; Siew-Lee Goh; Nathalie Champagne; Jacques Côté; Xiang-Jiao Yang
Journal:  Mol Cell Biol       Date:  2008-09-15       Impact factor: 4.272

10.  The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.

Authors:  Igor Garkavtsev; Sergey V Kozin; Olga Chernova; Lei Xu; Frank Winkler; Edward Brown; Gene H Barnett; Rakesh K Jain
Journal:  Nature       Date:  2004-03-18       Impact factor: 49.962
View more
  17 in total

1.  1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain.

Authors:  Emmanuel H Demont; Paul Bamborough; Chun-Wa Chung; Peter D Craggs; David Fallon; Laurie J Gordon; Paola Grandi; Clare I Hobbs; Jameed Hussain; Emma J Jones; Armelle Le Gall; Anne-Marie Michon; Darren J Mitchell; Rab K Prinjha; Andy D Roberts; Robert J Sheppard; Robert J Watson
Journal:  ACS Med Chem Lett       Date:  2014-09-10       Impact factor: 4.345

2.  Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor.

Authors:  Wylie S Palmer; Guillaume Poncet-Montange; Gang Liu; Alessia Petrocchi; Naphtali Reyna; Govindan Subramanian; Jay Theroff; Anne Yau; Maria Kost-Alimova; Jennifer P Bardenhagen; Elisabetta Leo; Hannah E Shepard; Trang N Tieu; Xi Shi; Yanai Zhan; Shuping Zhao; Michelle C Barton; Giulio Draetta; Carlo Toniatti; Philip Jones; Mary Geck Do; Jannik N Andersen
Journal:  J Med Chem       Date:  2015-07-06       Impact factor: 7.446

Review 3.  Biological function and histone recognition of family IV bromodomain-containing proteins.

Authors:  Jonathan T Lloyd; Karen C Glass
Journal:  J Cell Physiol       Date:  2017-06-13       Impact factor: 6.384

4.  Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2.

Authors:  Xiaozhe Xiong; Tatyana Panchenko; Shuang Yang; Shuai Zhao; Peiqiang Yan; Wenhao Zhang; Wei Xie; Yuanyuan Li; Yingming Zhao; C David Allis; Haitao Li
Journal:  Nat Chem Biol       Date:  2016-10-24       Impact factor: 15.040

5.  Copy number variants in a population-based investigation of Klippel-Trenaunay syndrome.

Authors:  Aggeliki Dimopoulos; Robert J Sicko; Denise M Kay; Shannon L Rigler; Ruzong Fan; Paul A Romitti; Marilyn L Browne; Charlotte M Druschel; Michele Caggana; Lawrence C Brody; James L Mills
Journal:  Am J Med Genet A       Date:  2016-11-30       Impact factor: 2.802

6.  Widespread colocalization of the Drosophila histone acetyltransferase homolog MYST5 with DREF and insulator proteins at active genes.

Authors:  Christiane Heseding; Harald Saumweber; Christina Rathke; Ann E Ehrenhofer-Murray
Journal:  Chromosoma       Date:  2016-02-19       Impact factor: 4.316

Review 7.  Structural features and inhibitors of bromodomains.

Authors:  Jamel Meslamani; Steven G Smith; Roberto Sanchez; Ming-Ming Zhou
Journal:  Drug Discov Today Technol       Date:  2016-09-22

8.  Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain.

Authors:  Mulu Y Lubula; Brian E Eckenroth; Samuel Carlson; Amanda Poplawski; Maksymilian Chruszcz; Karen C Glass
Journal:  FEBS Lett       Date:  2014-09-30       Impact factor: 4.124

9.  Crystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligands.

Authors:  Mulu Y Lubula; Amanda Poplawaski; Karen C Glass
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-09-25       Impact factor: 1.056

10.  Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3.

Authors:  Sophia Kim; Senthil Natesan; Gabriel Cornilescu; Samuel Carlson; Marco Tonelli; Urszula L McClurg; Olivier Binda; Craig N Robson; John L Markley; Stefan Balaz; Karen C Glass
Journal:  J Biol Chem       Date:  2016-06-08       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.