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Literature DB >> 24631743

Ethanolic carbon-11 chemistry: the introduction of green radiochemistry.

Xia Shao¹, Maria V Fawaz¹, Keunsam Jang¹, Peter J H Scott².

Abstract

The principles of green chemistry have been applied to a radiochemistry setting. Eleven carbon-11 labeled radiopharmaceuticals have been prepared using ethanol as the only organic solvent throughout the entire manufacturing process. The removal of all other organic solvents from the process simplifies production and quality control (QC) testing, moving our PET Center towards the first example of a green radiochemistry laboratory. All radiopharmaceutical doses prepared are suitable for clinical use.

Entities: Chemical Disease Gene Species

Keywords: Carbon-11; Green chemistry; PET chemistry; Positron emission tomography; Radiopharmaceutical synthesis

Mesh：

Substances：

Year: 2014 PMID： 24631743 PMCID： PMC4035440 DOI： 10.1016/j.apradiso.2014.01.033

Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513

15 in total

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Journal: Chem Rev Date: 2007-06 Impact factor: 60.622

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Journal: Angew Chem Int Ed Engl Date: 2008 Impact factor: 15.336

5. Methods for the incorporation of carbon-11 to generate radiopharmaceuticals for PET imaging.

Authors: Peter J H Scott
Journal: Angew Chem Int Ed Engl Date: 2009 Impact factor: 15.336

6. Green chemistry for chemical synthesis.

Authors: Chao-Jun Li; Barry M Trost
Journal: Proc Natl Acad Sci U S A Date: 2008-09-03 Impact factor: 11.205

Review 7. Molecular imaging with PET.

Authors: Simon M Ametamey; Michael Honer; Pius August Schubiger
Journal: Chem Rev Date: 2008-04-22 Impact factor: 60.622

8. Radiotracer synthesis from [(11)C]-iodomethane: a remarkably simple captive solvent method.

Authors: A A Wilson; A Garcia; L Jin; S Houle
Journal: Nucl Med Biol Date: 2000-08 Impact factor: 2.408

9. Studies into radiolytic decomposition of fluorine-18 labeled radiopharmaceuticals for positron emission tomography.

Authors: Peter J H Scott; Brian G Hockley; Hank F Kung; Rajesh Manchanda; Wei Zhang; Michael R Kilbourn
Journal: Appl Radiat Isot Date: 2008-09-07 Impact factor: 1.513

10. Radiolysis of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) and the role of reductant stabilisers.

Authors: Richard M Fawdry
Journal: Appl Radiat Isot Date: 2007-06-26 Impact factor: 1.513

3 in total

1. Automated Synthesis of ¹⁸F-BCPP-EF {2-tert-Butyl-4-Chloro-5-{6-[2-(2[¹⁸F]fluoroethoxy)-Ethoxy]-Pyridin-3-ylmethoxy}-2H-Pyridazin-3-One for Imaging of Mitochondrial Complex 1 in Parkinson's Disease.

Authors: Tanpreet Kaur; Allen F Brooks; Katherine M Liddell; Bradford D Henderson; Brian G Hockley; Nicolaas I Bohnen; Roger L Albin; Peter J H Scott
Journal: Front Chem Date: 2022-03-30 Impact factor: 5.221

Review 2. Late-Stage Carbon-14 Labeling and Isotope Exchange: Emerging Opportunities and Future Challenges.

Authors: Victor Babin; Frédéric Taran; Davide Audisio
Journal: JACS Au Date: 2022-06-07

3. Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC).

Authors: Isaac M Jackson; So Jeong Lee; Alexandra R Sowa; Melissa E Rodnick; Laura Bruton; Mara Clark; Sean Preshlock; Jill Rothley; Virginia E Rogers; Leslie E Botti; Bradford D Henderson; Brian G Hockley; Jovany Torres; David M Raffel; Allen F Brooks; Kirk A Frey; Michael R Kilbourn; Robert A Koeppe; Xia Shao; Peter J H Scott
Journal: EJNMMI Radiopharm Chem Date: 2020-11-11

3 in total