Literature DB >> 17669662

Radiolysis of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) and the role of reductant stabilisers.

Richard M Fawdry1.   

Abstract

2-[18F]Fluoro-2-deoxy-D-glucose (FDG) is unstable at elevated temperatures, alkaline pH and in highly radioactive concentrated solutions. Radiolysis generates hydrogen peroxide in situ that accelerates the FDG decomposition rate and shortens the shelf life of the radiopharmaceutical. Reductant stabilisers slow down the decomposition rate and improve the shelf life for large-scale FDG manufacture in highly radioactive concentrated solutions.

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Year:  2007        PMID： 17669662     DOI： 10.1016/j.apradiso.2007.05.011

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  9 in total

1.  Fully automated preparation and conjugation of N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) with RGD peptide using a GE FASTlab™ synthesizer.

Authors:  David Thonon; David Goblet; Eve Goukens; Geoffroy Kaisin; Jérôme Paris; Joël Aerts; Steve Lignon; Xavier Franci; Roland Hustinx; André Luxen
Journal:  Mol Imaging Biol       Date:  2011-12       Impact factor: 3.488

2.  Ethanolic carbon-11 chemistry: the introduction of green radiochemistry.

Authors:  Xia Shao; Maria V Fawaz; Keunsam Jang; Peter J H Scott
Journal:  Appl Radiat Isot       Date:  2014-02-15       Impact factor: 1.513

3.  Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.

Authors:  Jeffrey S Stehouwer; Matthew S Birnbaum; Ronald J Voll; Michael J Owens; Susan J Plott; Chase H Bourke; Michael A Wassef; Clinton D Kilts; Mark M Goodman
Journal:  Bioorg Med Chem       Date:  2015-06-19       Impact factor: 3.641

4.  Studies into radiolytic decomposition of fluorine-18 labeled radiopharmaceuticals for positron emission tomography.

Authors:  Peter J H Scott; Brian G Hockley; Hank F Kung; Rajesh Manchanda; Wei Zhang; Michael R Kilbourn
Journal:  Appl Radiat Isot       Date:  2008-09-07       Impact factor: 1.513

5.  Determination of radionuclides and radiochemical impurities produced by in-house cyclotron irradiation and subsequent radiosynthesis of PET tracers.

Authors:  Kiichi Ishiwata; Kunpei Hayashi; Masanari Sakai; Sugio Kawauchi; Hideaki Hasegawa; Jun Toyohara
Journal:  Ann Nucl Med       Date:  2016-10-15       Impact factor: 2.668

6.  Stability evaluation of [18F]FDG: literature study, stability studies from two different PET centres and future recommendations.

Authors:  Jes G Holler; Børge Renmælmo; Richard Fjellaksel
Journal:  EJNMMI Radiopharm Chem       Date:  2022-02-24

7.  Synthesis, Quality Control and Stability Studies of 2-[18F]Fluoro-2-Deoxy-D-Glucose(18F-FDG) at Different Conditions of Temperature by Physicochemical and Microbiological Assays.

Authors:  Siyavash Rahmani; Soraya Shahhoseini; Reza Mohamadi; Mostafa Vojdani
Journal:  Iran J Pharm Res       Date:  2017       Impact factor: 1.696

8.  Practical Consideration Regarding Stability of F-18 2-Deoxy-2-[18F] Fluoro-D-Glucose, Procured from a Distant Commercial Production Site.

Authors:  Rakhee Vatsa; Harmandeep Singh; Nivedita Rana; Rajender Kumar; Bhagwant Rai Mittal
Journal:  Indian J Nucl Med       Date:  2019-12-31

9.  Oxidant and Antioxidant Effects of Gentisic Acid in a <sup>177</sup>Lu-Labelled Methionine-Containing Minigastrin Analogue.

Authors:  Victoria Trindade; Henia Balter
Journal:  Curr Radiopharm       Date:  2020
  9 in total

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