| Literature DB >> 15388122 |
T Fukumura1, R Nakao, M Yamaguchi, K Suzuki.
Abstract
The stability of widely used 11C-radiopharmaceuticals was investigated. The purity of many 11C-radiopharmaceuticals was found to be low even at the end of synthesis and to lower with time by radiolysis. Examinations of the effects of radical scavengers showed that the radiopharmaceuticals were classified into four groups: Group 1 showing excellent stability; Group 2 showing suppressed radiolysis in the presence of a selective scavenger of hydroxyl radicals; Group 3 showing suppression in the presence of a selective scavenger of hydrated electrons; Group 4 showing suppression in the presence of both scavengers. Using appropriate additives according to these classes, 11C-radiopharmaceuticals were prepared with excellent radiochemical purity even with high levels of radioactivity and specific activity.Entities:
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Year: 2004 PMID： 15388122 DOI： 10.1016/j.apradiso.2004.04.011
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513