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Literature DB >> 24630899

Nonhomologous end joining: a good solution for bad ends.

Crystal A Waters¹, Natasha T Strande², David W Wyatt³, John M Pryor⁴, Dale A Ramsden⁵.

Abstract

Double strand breaks pose unique problems for DNA repair, especially when broken ends possess complex structures that interfere with standard DNA transactions. Nonhomologous end joining can use multiple strategies to solve these problems. It further uses sophisticated means to ensure the strategy chosen provides the ideal balance of flexibility and accuracy.

Entities: CellLine Chemical Disease Gene Species

Keywords: DNA damage; Double strand break repair; Nonhomologous end joining

Mesh：

Substances：
DNA Repair Enzymes

Year: 2014 PMID： 24630899 PMCID： PMC4024359 DOI： 10.1016/j.dnarep.2014.02.008

Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856

154 in total

Review 1. Targeting DNA topoisomerase II in cancer chemotherapy.

Authors: John L Nitiss
Journal: Nat Rev Cancer Date: 2009-04-20 Impact factor: 60.716

2. Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4.

Authors: Peï-Yu Wu; Philippe Frit; SriLakshmi Meesala; Stéphanie Dauvillier; Mauro Modesti; Sara N Andres; Ying Huang; JoAnn Sekiguchi; Patrick Calsou; Bernard Salles; Murray S Junop
Journal: Mol Cell Biol Date: 2009-03-30 Impact factor: 4.272

3. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.

Authors: R Scott Williams; Gabriel Moncalian; Jessica S Williams; Yoshiki Yamada; Oliver Limbo; David S Shin; Lynda M Groocock; Dana Cahill; Chiharu Hitomi; Grant Guenther; Davide Moiani; James P Carney; Paul Russell; John A Tainer
Journal: Cell Date: 2008-10-03 Impact factor: 41.582

Review 4. Single-strand break repair and genetic disease.

Authors: Keith W Caldecott
Journal: Nat Rev Genet Date: 2008-08 Impact factor: 53.242

5. Interplay of two major repair pathways in the processing of complex double-strand DNA breaks.

Authors: Tracey A Dobbs; Philip Palmer; Zoitsa Maniou; Martine E Lomax; Peter O'Neill
Journal: DNA Repair (Amst) Date: 2008-06-20

6. Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin.

Authors: Ulrich Rass; Ivan Ahel; Stephen C West
Journal: J Biol Chem Date: 2008-10-03 Impact factor: 5.157

Review 7. DNA-PK: the means to justify the ends?

Authors: Katheryn Meek; Van Dang; Susan P Lees-Miller
Journal: Adv Immunol Date: 2008 Impact factor: 3.543

8. The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining.

Authors: Robert Hromas; Justin Wray; Suk-Hee Lee; Leah Martinez; Jacqueline Farrington; Lori Kwan Corwin; Heather Ramsey; Jac A Nickoloff; Elizabeth A Williamson
Journal: DNA Repair (Amst) Date: 2008-09-18

9. DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.

Authors: Yaping Yu; Brandi L Mahaney; Ken-Ichi Yano; Ruiqiong Ye; Shujuan Fang; Pauline Douglas; David J Chen; Susan P Lees-Miller
Journal: DNA Repair (Amst) Date: 2008-08-03

10. Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair.

Authors: Daniel Lucas; Beatriz Escudero; José Manuel Ligos; Jose Carlos Segovia; Juan Camilo Estrada; Gloria Terrados; Luis Blanco; Enrique Samper; Antonio Bernad
Journal: PLoS Genet Date: 2009-02-20 Impact factor: 5.917

57 in total

1. Structural evidence for an in trans base selection mechanism involving Loop1 in polymerase μ at an NHEJ double-strand break junction.

Authors: Jérôme Loc'h; Christina A Gerodimos; Sandrine Rosario; Mustafa Tekpinar; Michael R Lieber; Marc Delarue
Journal: J Biol Chem Date: 2019-05-28 Impact factor: 5.157

2. Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining.

Authors: John M Pryor; Michael P Conlin; Juan Carvajal-Garcia; Megan E Luedeman; Adam J Luthman; George W Small; Dale A Ramsden
Journal: Science Date: 2018-09-14 Impact factor: 47.728

3. Characterization of DNA binding and pairing activities associated with the native SFPQ·NONO DNA repair protein complex.

Authors: Durga Udayakumar; William S Dynan
Journal: Biochem Biophys Res Commun Date: 2015-05-18 Impact factor: 3.575

Nonhomologous end joining: a good solution for bad ends.

Review 1. Targeting DNA topoisomerase II in cancer chemotherapy.

2. Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4.

3. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.

Review 4. Single-strand break repair and genetic disease.

5. Interplay of two major repair pathways in the processing of complex double-strand DNA breaks.

6. Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin.

Review 7. DNA-PK: the means to justify the ends?

8. The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining.

9. DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.

10. Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair.

1. Structural evidence for an in trans base selection mechanism involving Loop1 in polymerase μ at an NHEJ double-strand break junction.

2. Ribonucleotide incorporation enables repair of chromosome breaks by nonhomologous end joining.

3. Characterization of DNA binding and pairing activities associated with the native SFPQ·NONO DNA repair protein complex.

4. What a 'Ku'incidence!: parallel discoveries of a new DNA repair factor.

5. TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.

6. Regulation of human polλ by ATM-mediated phosphorylation during non-homologous end joining.

Review 7. Control of gene editing by manipulation of DNA repair mechanisms.

Review 8. Error-Prone Repair of DNA Double-Strand Breaks.

9. Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans.

10. Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.