Baodong Qin1, Jiangyan Li1, Yan Liang1, Zaixing Yang2, Renqian Zhong3. 1. Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China. 2. Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address: yangzaixingdiyi@163.com. 3. Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China. Electronic address: rqzhong@yahoo.com.
Abstract
BACKGROUND: Several previous studies have assessed the association of Cytotoxic T Lymphocyte Associated Antigen-4, Fas, and Tumour Necrosis Factor-α gene polymorphisms with autoimmune hepatitis risk, but the results were inconsistent and inconclusive. We performed a meta-analysis to better evaluate these associations. METHODS: PubMed, EMBASE and MEDLINE were searched in all languages. Overall odd ratios with 95% confidence intervals were calculated to assess the strength of associations using a fixed-effects or random-effects models. RESULTS: 15 relevant studies were identified. No significant association was found between CTLA-4+49A/G and AH. TNF-α-308A/G was significantly associated with autoimmune hepatitis risk. Individuals with the "A" allele had a 67% increased risk of autoimmune hepatitis (odds ratio=1.67, 95% confidence interval 1.11-2.52). The genotype "AA" was a potential predisposing factor for autoimmune hepatitis, when compared with the genotype "GG" and "AG+GG" (odds ratio=2.71, 95% confidence interval 1.12-6.57; odds ratio=2.14, 95% confidence interval 1.30-3.52). Besides, no significant association was found between the Fas-670G/A and TNF-α-238A/G polymorphisms and autoimmune hepatitis risk using any model. CONCLUSION: The meta-analysis identified the TNF-α-308 "A" allele as a predisposing factor for autoimmune hepatitis, whereas the genotype "GG" was a protective factor. This study did not find a significant association between CTLA-4+49A/G, Fas-670G/A, TNF-α-238A/G and susceptibility to autoimmune hepatitis.
BACKGROUND: Several previous studies have assessed the association of Cytotoxic T Lymphocyte Associated Antigen-4, Fas, and Tumour Necrosis Factor-α gene polymorphisms with autoimmune hepatitis risk, but the results were inconsistent and inconclusive. We performed a meta-analysis to better evaluate these associations. METHODS: PubMed, EMBASE and MEDLINE were searched in all languages. Overall odd ratios with 95% confidence intervals were calculated to assess the strength of associations using a fixed-effects or random-effects models. RESULTS: 15 relevant studies were identified. No significant association was found between CTLA-4+49A/G and AH. TNF-α-308A/G was significantly associated with autoimmune hepatitis risk. Individuals with the "A" allele had a 67% increased risk of autoimmune hepatitis (odds ratio=1.67, 95% confidence interval 1.11-2.52). The genotype "AA" was a potential predisposing factor for autoimmune hepatitis, when compared with the genotype "GG" and "AG+GG" (odds ratio=2.71, 95% confidence interval 1.12-6.57; odds ratio=2.14, 95% confidence interval 1.30-3.52). Besides, no significant association was found between the Fas-670G/A and TNF-α-238A/G polymorphisms and autoimmune hepatitis risk using any model. CONCLUSION: The meta-analysis identified the TNF-α-308 "A" allele as a predisposing factor for autoimmune hepatitis, whereas the genotype "GG" was a protective factor. This study did not find a significant association between CTLA-4+49A/G, Fas-670G/A, TNF-α-238A/G and susceptibility to autoimmune hepatitis.
Authors: C R Grant; B S Holder; R Liberal; M A Heneghan; Y Ma; G Mieli-Vergani; D Vergani; M S Longhi Journal: Clin Exp Immunol Date: 2017-03-27 Impact factor: 4.330