Literature DB >> 24622617

Realizing the potential of synthetic biology.

George M Church1, Michael B Elowitz2, Christina D Smolke3, Christopher A Voigt4, Ron Weiss5.   

Abstract

Synthetic biology, despite still being in its infancy, is increasingly providing valuable information for applications in the clinic, the biotechnology industry and in basic molecular research. Both its unique potential and the challenges it presents have brought together the expertise of an eclectic group of scientists, from cell biologists to engineers. In this Viewpoint article, five experts discuss their views on the future of synthetic biology, on its main achievements in basic and applied science, and on the bioethical issues that are associated with the design of new biological systems.

Mesh:

Year:  2014        PMID: 24622617     DOI: 10.1038/nrm3767

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN: 1471-0072            Impact factor:   94.444


  35 in total

1.  j5 DNA assembly design automation software.

Authors:  Nathan J Hillson; Rafael D Rosengarten; Jay D Keasling
Journal:  ACS Synth Biol       Date:  2011-12-20       Impact factor: 5.110

2.  Synthetic biology.

Authors:  Christopher A Voigt
Journal:  ACS Synth Biol       Date:  2012-01-20       Impact factor: 5.110

3.  Characterization of the reconstructed 1918 Spanish influenza pandemic virus.

Authors:  Terrence M Tumpey; Christopher F Basler; Patricia V Aguilar; Hui Zeng; Alicia Solórzano; David E Swayne; Nancy J Cox; Jacqueline M Katz; Jeffery K Taubenberger; Peter Palese; Adolfo García-Sastre
Journal:  Science       Date:  2005-10-07       Impact factor: 47.728

Review 4.  Engineered gene circuits.

Authors:  Jeff Hasty; David McMillen; J J Collins
Journal:  Nature       Date:  2002-11-14       Impact factor: 49.962

5.  Informing biological design by integration of systems and synthetic biology.

Authors:  Christina D Smolke; Pamela A Silver
Journal:  Cell       Date:  2011-03-18       Impact factor: 41.582

6.  Programming cells by multiplex genome engineering and accelerated evolution.

Authors:  Harris H Wang; Farren J Isaacs; Peter A Carr; Zachary Z Sun; George Xu; Craig R Forest; George M Church
Journal:  Nature       Date:  2009-07-26       Impact factor: 49.962

7.  antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences.

Authors:  Marnix H Medema; Kai Blin; Peter Cimermancic; Victor de Jager; Piotr Zakrzewski; Michael A Fischbach; Tilmann Weber; Eriko Takano; Rainer Breitling
Journal:  Nucleic Acids Res       Date:  2011-06-14       Impact factor: 16.971

8.  Writing DNA with GenoCAD.

Authors:  Michael J Czar; Yizhi Cai; Jean Peccoud
Journal:  Nucleic Acids Res       Date:  2009-05-08       Impact factor: 16.971

9.  Design of orthogonal genetic switches based on a crosstalk map of σs, anti-σs, and promoters.

Authors:  Virgil A Rhodius; Thomas H Segall-Shapiro; Brian D Sharon; Amar Ghodasara; Ekaterina Orlova; Hannah Tabakh; David H Burkhardt; Kevin Clancy; Todd C Peterson; Carol A Gross; Christopher A Voigt
Journal:  Mol Syst Biol       Date:  2013-10-29       Impact factor: 11.429

10.  A fast, robust and tunable synthetic gene oscillator.

Authors:  Jesse Stricker; Scott Cookson; Matthew R Bennett; William H Mather; Lev S Tsimring; Jeff Hasty
Journal:  Nature       Date:  2008-10-29       Impact factor: 49.962

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  50 in total

1.  Evolution of a split RNA polymerase as a versatile biosensor platform.

Authors:  Jinyue Pu; Julia Zinkus-Boltz; Bryan C Dickinson
Journal:  Nat Chem Biol       Date:  2017-02-13       Impact factor: 15.040

2.  A Synthetic-Biology-Inspired Therapeutic Strategy for Targeting and Treating Hepatogenous Diabetes.

Authors:  Shuai Xue; Jianli Yin; Jiawei Shao; Yuanhuan Yu; Linfeng Yang; Yidan Wang; Mingqi Xie; Martin Fussenegger; Haifeng Ye
Journal:  Mol Ther       Date:  2017-02-01       Impact factor: 11.454

3.  Focus Issue Editorial: Synthetic Biology.

Authors:  Andrew D Hanson; Julian M Hibberd; Mattheos A G Koffas; Joachim Kopka; Eleanore T Wurtzel
Journal:  Plant Physiol       Date:  2019-03       Impact factor: 8.340

4.  Molecular circuits for dynamic noise filtering.

Authors:  Christoph Zechner; Georg Seelig; Marc Rullan; Mustafa Khammash
Journal:  Proc Natl Acad Sci U S A       Date:  2016-04-12       Impact factor: 11.205

Review 5.  TRIENNIAL LACTATION SYMPOSIUM/BOLFA:Historical perspectives of lactation biology in the late 20th and early 21st centuries.

Authors:  R J Collier; D E Bauman
Journal:  J Anim Sci       Date:  2017-12       Impact factor: 3.159

6.  A Panel of Protease-Responsive RNA Polymerases Respond to Biochemical Signals by Production of Defined RNA Outputs in Live Cells.

Authors:  Jinyue Pu; Ian Chronis; Daniel Ahn; Bryan C Dickinson
Journal:  J Am Chem Soc       Date:  2015-12-17       Impact factor: 15.419

7.  RNA Polymerase Tags To Monitor Multidimensional Protein-Protein Interactions Reveal Pharmacological Engagement of Bcl-2 Proteins.

Authors:  Jinyue Pu; Jeffrey A Dewey; Abbas Hadji; James L LaBelle; Bryan C Dickinson
Journal:  J Am Chem Soc       Date:  2017-08-15       Impact factor: 15.419

8.  Synthetic Biology, Genome Editing, and the Risk of Bioterrorism.

Authors:  Marko Ahteensuu
Journal:  Sci Eng Ethics       Date:  2017-01-10       Impact factor: 3.777

Review 9.  Microbial engineering to produce fatty alcohols and alkanes.

Authors:  Ashima Sharma; Syed Shams Yazdani
Journal:  J Ind Microbiol Biotechnol       Date:  2021-04-30       Impact factor: 4.258

Review 10.  Designer cell signal processing circuits for biotechnology.

Authors:  Robert W Bradley; Baojun Wang
Journal:  N Biotechnol       Date:  2015-01-08       Impact factor: 5.079

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