PROBLEM: Cytomegalovirus (CMV) infection was previously reported in pregnancy complications. However, its seroprevalence and associated Toll-like receptor (TLR) expression in early-onset preeclampsia (EOPE) with hemolysis, elevated liver enzyme and low platelets syndrome (HELLPs) are unexplored. METHOD OF STUDY: A case–control study was performed to examine maternal CMV antibodies, neutrophil Toll-like receptor (TLR)-2 and -4 expression as well as the cytokine profile in EOPE with HELLPs (EOPE-HELLPs) (n = 10), late-onset preeclampsia (LOPE) (n = 20), normal pregnancy (n = 60), and non-pregnancy (n = 20) controls. RESULTS: EOPE-HELLPs had significantly increased CMV IgG sero-positivity, upregulated TLR-2/-4 mRNA expression, increased serum IL-6 and TNF-α, and reduced IL-10 compared with matched normal and non-pregnancy controls. No significant difference was observed between LOPE and normal pregnancy controls. CONCLUSION: We observed a significant association between CMV IgG sero-positivity and innate immune response in EOPE-HELLPs. Our data suggest that CMV infection may be a risk factor for this disorder.
PROBLEM: Cytomegalovirus (CMV) infection was previously reported in pregnancy complications. However, its seroprevalence and associated Toll-like receptor (TLR) expression in early-onset preeclampsia (EOPE) with hemolysis, elevated liver enzyme and low platelets syndrome (HELLPs) are unexplored. METHOD OF STUDY: A case–control study was performed to examine maternal CMV antibodies, neutrophil Toll-like receptor (TLR)-2 and -4 expression as well as the cytokine profile in EOPE with HELLPs (EOPE-HELLPs) (n = 10), late-onset preeclampsia (LOPE) (n = 20), normal pregnancy (n = 60), and non-pregnancy (n = 20) controls. RESULTS: EOPE-HELLPs had significantly increased CMV IgG sero-positivity, upregulated TLR-2/-4 mRNA expression, increased serum IL-6 and TNF-α, and reduced IL-10 compared with matched normal and non-pregnancy controls. No significant difference was observed between LOPE and normal pregnancy controls. CONCLUSION: We observed a significant association between CMV IgG sero-positivity and innate immune response in EOPE-HELLPs. Our data suggest that CMV infection may be a risk factor for this disorder.
Authors: Fang Xie; Yuxiang Hu; Laura A Magee; Deborah M Money; David M Patrick; Mel Krajden; Eva Thomas; Peter von Dadelszen Journal: Acta Obstet Gynecol Scand Date: 2010-09 Impact factor: 3.636
Authors: F Xie; Y Hu; S E Turvey; L A Magee; R M Brunham; K-C Choi; M Krajden; P C K Leung; D M Money; D M Patrick; E Thomas; P von Dadelszen Journal: BJOG Date: 2010-01 Impact factor: 6.531
Authors: Bas B van Rijn; Arie Franx; Eric A P Steegers; Christianne J M de Groot; Rogier M Bertina; Gerard Pasterkamp; Hieronymus A M Voorbij; Hein W Bruinse; Mark Roest Journal: PLoS One Date: 2008-04-02 Impact factor: 3.240
Authors: Cosme Alvarado-Esquivel; Ada A Sandoval-Carrillo; Fernando Vazquez-Alaniz; José M Salas-Pacheco; Jesús Hernández-Tinoco; Luis Francisco Sánchez-Anguiano; Elizabeth Irasema Antuna-Salcido Journal: Eur J Microbiol Immunol (Bp) Date: 2017-07-13