Literature DB >> 15947178

Latest advances in understanding preeclampsia.

Christopher W Redman1, Ian L Sargent.   

Abstract

Preeclampsia is a relatively common pregnancy disorder that originates in the placenta and causes variable maternal and fetal problems. In the worst cases, it may threaten the survival of both mother and baby. We summarize recent work on the causes of preeclampsia, which reveals a new mode of maternal immune recognition of the fetus, relevant to the condition. The circulating factors derived from the placenta, which contributes to the clinical syndrome, are now better understood. This brief review on preeclampsia does not cover all aspects of this intriguing condition but focuses on some new and interesting findings.

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Year:  2005        PMID: 15947178     DOI: 10.1126/science.1111726

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  699 in total

1.  Association between genetic polymorphisms in androgen receptor gene and the risk of preeclampsia in Korean women.

Authors:  Ji Hyae Lim; Shinyoung Kim; Si Won Lee; So Yeon Park; Jung Yeol Han; Jin Hoon Chung; Moon Young Kim; Jae Hyug Yang; Hyun Mee Ryu
Journal:  J Assist Reprod Genet       Date:  2010-10-05       Impact factor: 3.412

2.  Glucose and metformin modulate human first trimester trophoblast function: a model and potential therapy for diabetes-associated uteroplacental insufficiency.

Authors:  Christina S Han; Melissa A Herrin; Mary C Pitruzzello; Melissa J Mulla; Erika F Werner; Christian M Pettker; Clare A Flannery; Vikki M Abrahams
Journal:  Am J Reprod Immunol       Date:  2014-11-14       Impact factor: 3.886

3.  L-arginine supplementation abolishes the blood pressure and endothelin response to chronic increases in plasma sFlt-1 in pregnant rats.

Authors:  Sydney R Murphy; Babbette LaMarca; Kathy Cockrell; Marietta Arany; Joey P Granger
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-11-09       Impact factor: 3.619

4.  17-hydroxyprogesterone caproate significantly improves clinical characteristics of preeclampsia in the reduced uterine perfusion pressure rat model.

Authors:  Lorena M Amaral; Denise C Cornelius; Ashlyn Harmon; Janae Moseley; James N Martin; Babbette LaMarca
Journal:  Hypertension       Date:  2014-11-03       Impact factor: 10.190

5.  Identification of the primary outcomes that result from deficient spiral arterial modification in pregnant mice.

Authors:  B Anne Croy; Suzanne D Burke; Valerie F Barrette; Jianhong Zhang; Kota Hatta; Graeme N Smith; Juares Bianco; Aureo T Yamada; Michael A Adams
Journal:  Pregnancy Hypertens       Date:  2011-01-01       Impact factor: 2.899

6.  Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta.

Authors:  Wen Wang; Lin Feng; Honghai Zhang; Stephanie Hachy; Seiro Satohisa; Louise C Laurent; Mana Parast; Jing Zheng; Dong-bao Chen
Journal:  J Clin Endocrinol Metab       Date:  2012-03-21       Impact factor: 5.958

7.  The two stage model of preeclampsia: variations on the theme.

Authors:  J M Roberts; C A Hubel
Journal:  Placenta       Date:  2008-12-13       Impact factor: 3.481

8.  New Insights into the Pathogenesis of Preeclampsia - The Role of Nrf2 Activators and their Potential Therapeutic Impact.

Authors:  N Kweider; C J Wruck; W Rath
Journal:  Geburtshilfe Frauenheilkd       Date:  2013-12       Impact factor: 2.915

9.  Role of hypoxia-inducible transcription factors 1alpha and 2alpha in the regulation of plasminogen activator inhibitor-1 expression in a human trophoblast cell line.

Authors:  E S Meade; Y Y Ma; S Guller
Journal:  Placenta       Date:  2007-06-13       Impact factor: 3.481

Review 10.  Proteinuria in preeclampsia from a podocyte injury perspective.

Authors:  Daniel E Henao; Moin A Saleem
Journal:  Curr Hypertens Rep       Date:  2013-12       Impact factor: 5.369

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