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Literature DB >> 24610814

A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.

Sarah A Slavoff¹, Jinho Heo, Bogdan A Budnik, Leslyn A Hanakahi, Alan Saghatelian.

Abstract

The recent discovery of numerous human short open reading frame (sORF)-encoded polypeptides (SEPs) has raised important questions about the functional roles of these molecules in cells. Here, we show that a 69-amino acid SEP, MRI-2, physically interacts with the Ku heterodimer to stimulate DNA double-strand break ligation via nonhomologous end joining. The characterization of MRI-2 suggests that this SEP may participate in DNA repair and underscores the potential of SEPs to serve important biological functions in mammalian cells.

Entities: Chemical Gene Species

Keywords: DNA Repair; Peptide Interactions; Peptides; Protein-Protein Interactions; Proteomics; Short ORF

Mesh：

Substances：

Year: 2014 PMID： 24610814 PMCID： PMC4036235 DOI： 10.1074/jbc.C113.533968

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

41 in total

1. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.

Authors: J R Walker; R A Corpina; J Goldberg
Journal: Nature Date: 2001-08-09 Impact factor: 49.962

2. Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection.

Authors: L Li; J M Olvera; K E Yoder; R S Mitchell; S L Butler; M Lieber; S L Martin; F D Bushman
Journal: EMBO J Date: 2001-06-15 Impact factor: 11.598

3. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta.

Authors: Y Hashimoto; T Niikura; H Tajima; T Yasukawa; H Sudo; Y Ito; Y Kita; M Kawasumi; K Kouyama; M Doyu; G Sobue; T Koide; S Tsuji; J Lang; K Kurokawa; I Nishimoto
Journal: Proc Natl Acad Sci U S A Date: 2001-05-22 Impact factor: 11.205

4. 2-Step purification of the Ku DNA repair protein expressed in Escherichia coli.

Authors: Les A Hanakahi
Journal: Protein Expr Purif Date: 2006-10-10 Impact factor: 1.650

5. Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein.

Authors: Y Hashimoto; Y Ito; T Niikura; Z Shao; M Hata; F Oyama; I Nishimoto
Journal: Biochem Biophys Res Commun Date: 2001-05-04 Impact factor: 3.575

6. Pyruvate kinase M2 is a phosphotyrosine-binding protein.

Authors: Heather R Christofk; Matthew G Vander Heiden; Ning Wu; John M Asara; Lewis C Cantley
Journal: Nature Date: 2008-03-13 Impact factor: 49.962

7. Small peptide regulators of actin-based cell morphogenesis encoded by a polycistronic mRNA.

Authors: Takefumi Kondo; Yoshiko Hashimoto; Kagayaki Kato; Sachi Inagaki; Shigeo Hayashi; Yuji Kageyama
Journal: Nat Cell Biol Date: 2007-05-07 Impact factor: 28.824

8. Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding.

Authors: D Michaelson; J Silletti; G Murphy; P D'Eustachio; M Rush; M R Philips
Journal: J Cell Biol Date: 2001-01-08 Impact factor: 10.539

9. Small-scale extracts for the study of nucleotide excision repair and non-homologous end joining.

Authors: Michael B Smeaton; Paul S Miller; Gary Ketner; Les A Hanakahi
Journal: Nucleic Acids Res Date: 2007-12-10 Impact factor: 16.971

10. Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase.

Authors: Joyce C Y Cheung; Brenda Salerno; Les A Hanakahi
Journal: Nucleic Acids Res Date: 2008-09-06 Impact factor: 16.971

59 in total

A human short open reading frame (sORF)-encoded polypeptide that stimulates DNA end joining.

1. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.

2. Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection.

3. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta.

4. 2-Step purification of the Ku DNA repair protein expressed in Escherichia coli.

5. Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein.

6. Pyruvate kinase M2 is a phosphotyrosine-binding protein.

7. Small peptide regulators of actin-based cell morphogenesis encoded by a polycistronic mRNA.

8. Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding.

9. Small-scale extracts for the study of nucleotide excision repair and non-homologous end joining.

10. Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase.

1. MIEF1 Microprotein Regulates Mitochondrial Translation.

Review 2. The role of micropeptides in biology.

3. Pervasive functional translation of noncanonical human open reading frames.

4. Improved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides.

5. Upstream ORFs are prevalent translational repressors in vertebrates.

Review 6. Identifying (non-)coding RNAs and small peptides: challenges and opportunities.

Review 7. The molecular basis and disease relevance of non-homologous DNA end joining.

Review 8. Identification and characterization of sORF-encoded polypeptides.

Review 9. Nonhomologous DNA end-joining for repair of DNA double-strand breaks.

Review 10. Discovery and characterization of smORF-encoded bioactive polypeptides.