| Literature DB >> 24599278 |
Ya Ding1, Ziwen Jiang2, Krishnendu Saha2, Chang Soo Kim2, Sung Tae Kim2, Ryan F Landis2, Vincent M Rotello3.
Abstract
Gold nanoparticles provide an attractive and applicable scaffold for delivery of nucleic acids. In this review, we focus on the use of covalent and noncovalent gold nanoparticle conjugates for applications in gene delivery and RNA-interference technologies. We also discuss challenges in nucleic acid delivery, including endosomal entrapment/escape and active delivery/presentation of nucleic acids in the cell.Entities:
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Year: 2014 PMID： 24599278 PMCID： PMC4048892 DOI： 10.1038/mt.2014.30
Source DB: PubMed Journal: Mol Ther ISSN： 1525-0016 Impact factor: 11.454