Literature DB >> 24576896

Impact of genomic damage and ageing on stem cell function.

Axel Behrens1, Jan M van Deursen2, K Lenhard Rudolph3, Björn Schumacher4.   

Abstract

Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation of DNA damage in both stem cells and cells that comprise the stem cell microenvironment are partly responsible for stem cell dysfunction with ageing. Here, we review the impact of the various types of DNA damage that accumulate with ageing on stem cell functionality, as well as the development of cancer. We discuss DNA-damage-induced cell intrinsic and extrinsic alterations that influence these processes, and review recent advances in understanding systemic adjustments to DNA damage and how they affect stem cells.

Entities:  

Mesh：

Year:  2014        PMID： 24576896      PMCID： PMC4214082          DOI： 10.1038/ncb2928

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  98 in total

Review 1.  ATR: an essential regulator of genome integrity.

Authors:  Karlene A Cimprich; David Cortez
Journal:  Nat Rev Mol Cell Biol       Date:  2008-07-02       Impact factor: 94.444

2.  A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis.

Authors:  Andrew S Brack; Irina M Conboy; Michael J Conboy; Jeanne Shen; Thomas A Rando
Journal:  Cell Stem Cell       Date:  2008-01-10       Impact factor: 24.633

3.  Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.

Authors:  Yaroslava Ruzankina; Carolina Pinzon-Guzman; Amma Asare; Tony Ong; Laura Pontano; George Cotsarelis; Valerie P Zediak; Marielena Velez; Avinash Bhandoola; Eric J Brown
Journal:  Cell Stem Cell       Date:  2007-06-07       Impact factor: 24.633

4.  A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells.

Authors:  Rebecca H Cho; Hans B Sieburg; Christa E Muller-Sieburg
Journal:  Blood       Date:  2008-04-15       Impact factor: 22.113

Review 5.  DNA damage checkpoints: from initiation to recovery or adaptation.

Authors:  Jiri Bartek; Jiri Lukas
Journal:  Curr Opin Cell Biol       Date:  2007-02-15       Impact factor: 8.382

6.  Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.

Authors:  Zhenyu Ju; Hong Jiang; Maike Jaworski; Chozhavendan Rathinam; Anne Gompf; Christoph Klein; Andreas Trumpp; K Lenhard Rudolph
Journal:  Nat Med       Date:  2007-05-07       Impact factor: 53.440

7.  Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest.

Authors:  Keiyo Takubo; Masako Ohmura; Masaki Azuma; Go Nagamatsu; Wakako Yamada; Fumio Arai; Atsushi Hirao; Toshio Suda
Journal:  Cell Stem Cell       Date:  2008-02-07       Impact factor: 24.633

8.  Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis.

Authors:  Andrew S Brack; Michael J Conboy; Sudeep Roy; Mark Lee; Calvin J Kuo; Charles Keller; Thomas A Rando
Journal:  Science       Date:  2007-08-10       Impact factor: 47.728

9.  Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.

Authors:  Morgan E Carlson; Michael Hsu; Irina M Conboy
Journal:  Nature       Date:  2008-06-15       Impact factor: 49.962

10.  A population of myogenic stem cells that survives skeletal muscle aging.

Authors:  Charlotte A Collins; Peter S Zammit; Ana Pérez Ruiz; Jennifer E Morgan; Terence A Partridge
Journal:  Stem Cells       Date:  2007-01-11       Impact factor: 6.277
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  86 in total

1.  A Preliminary Study: Human Fibroid Stro-1+/CD44+ Stem Cells Isolated From Uterine Fibroids Demonstrate Decreased DNA Repair and Genomic Integrity Compared to Adjacent Myometrial Stro-1+/CD44+ Cells.

Authors:  Lauren E Prusinski Fernung; Ayman Al-Hendy; Qiwei Yang
Journal:  Reprod Sci       Date:  2018-06-28       Impact factor: 3.060

Review 2.  The Role of Aging in Idiopathic Pulmonary Fibrosis.

Authors:  Joseph Leung; Young Cho; Richard F Lockey; Narasaiah Kolliputi
Journal:  Lung       Date:  2015-04-23       Impact factor: 2.584

3.  Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability.

Authors:  Bo Zhao; Wei-Dao Zhang; Ying-Liang Duan; Yong-Qing Lu; Yi-Xian Cun; Chao-Hui Li; Kun Guo; Wen-Hui Nie; Lei Li; Rugang Zhang; Ping Zheng
Journal:  Cell Stem Cell       Date:  2015-04-30       Impact factor: 24.633

Review 4.  Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD.

Authors:  David A Ferenbach; Joseph V Bonventre
Journal:  Nat Rev Nephrol       Date:  2015-02-03       Impact factor: 28.314

Review 5.  Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease.

Authors:  Isabel Beerman; Derrick J Rossi
Journal:  Cell Stem Cell       Date:  2015-06-04       Impact factor: 24.633

6.  Longevity through DNA damage tolerance.

Authors:  Laia Castells-Roca; Michael M Mueller; Björn Schumacher
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

7.  Effect of lifelong football training on the expression of muscle molecular markers involved in healthy longevity.

Authors:  A Mancini; D Vitucci; G Labruna; E Imperlini; M B Randers; J F Schmidt; M Hagman; T R Andersen; R Russo; S Orrù; P Krustrup; F Salvatore; P Buono
Journal:  Eur J Appl Physiol       Date:  2017-03-01       Impact factor: 3.078

8.  Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling.

Authors:  Joana M Xavier; Ana L Morgado; Cecília Mp Rodrigues; Susana Solá
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

9.  Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells.

Authors:  Pedro Sousa-Victor; Arshad Ayyaz; Rippei Hayashi; Yanyan Qi; David T Madden; Victoria V Lunyak; Heinrich Jasper
Journal:  Cell Rep       Date:  2017-09-12       Impact factor: 9.423

Review 10.  Control of stress signaling in stem cells: crossroads of stem cells and cancer.

Authors:  Seung-Ju Cho; JaeHyung Koo; Kwang-Hoon Chun; Hyuk-Jin Cha
Journal:  Tumour Biol       Date:  2016-07-27
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