Literature DB >> 2457509

Serotonin is localized in endothelial cells of coronary arteries and released during hypoxia: a possible new mechanism for hypoxia-induced vasodilatation of the rat heart.

G Burnstock1, J Lincoln, E Fehér, A M Hopwood, K Kirkpatrick, P Milner, V Ralevic.   

Abstract

In this report we demonstrate the immunocytochemical localization of serotonin in endothelial cells of rat coronary vessels and a significant increase in the release of serotonin into the perfusate of Langendorff rat heart preparations during hypoxia. It is suggested that serotonin, localized in endothelial cells, is released during hypoxia and could provide part of a pathophysiological mechanism for vasodilatation to protect the heart from damage due to hypoxia.

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Year:  1988        PMID： 2457509     DOI： 10.1007/bf01941035

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  Balance between endothelium-mediated dilating and direct constricting actions of serotonin on resistance vessels in the isolated rabbit heart.

Authors:  D J Stewart; J Holtz; U Pohl; E Bassenge
Journal:  Eur J Pharmacol       Date:  1987-11-03       Impact factor: 4.432

2.  A simple, sensitive and reliable assay for serotonin and 5-HIAA in brain tissue using liquid chromatography with electrochemical detection.

Authors:  J F Reinhard; M A Moskowitz; A F Sved; J D Fernstrom
Journal:  Life Sci       Date:  1980-09-15       Impact factor: 5.037

3.  Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets.

Authors:  R A Cohen; J T Shepherd; P M Vanhoutte
Journal:  Science       Date:  1983-07-15       Impact factor: 47.728

4.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.

Authors:  R F Furchgott; J V Zawadzki
Journal:  Nature       Date:  1980-11-27       Impact factor: 49.962

5.  ATP mediates coronary vasoconstriction via P2x-purinoceptors and coronary vasodilatation via P2y-purinoceptors in the isolated perfused rat heart.

Authors:  A M Hopwood; G Burnstock
Journal:  Eur J Pharmacol       Date:  1987-04-07       Impact factor: 4.432

6.  5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries.

Authors:  R A Cohen; J T Shepherd; P M Vanhoutte
Journal:  Am J Physiol       Date:  1983-12

7.  Endothelial cells are involved in the vasodilatory response to hypoxia.

Authors:  R Busse; U Pohl; C Kellner; U Klemm
Journal:  Pflugers Arch       Date:  1983-04       Impact factor: 3.657

Review 8.  Mechanisms of interaction of peptide and nonpeptide vascular neurotransmitter systems.

Authors:  G Burnstock
Journal:  J Cardiovasc Pharmacol       Date:  1987       Impact factor: 3.105

9.  Ultrastructural localization of choline acetyltransferase in vascular endothelial cells in rat brain.

Authors:  J G Parnavelas; W Kelly; G Burnstock
Journal:  Nature       Date:  1985 Aug 22-28       Impact factor: 49.962

10.  Production of 5-hydroxyindoleacetic acid from serotonin by cultured endothelial cells.

Authors:  R Small; E Macarak; A B Fisher
Journal:  J Cell Physiol       Date:  1977-02       Impact factor: 6.384
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  15 in total

1.  Endothelin, vasopressin, and substance P like immunoreactivity in cultured and intact epithelium from rabbit trachea.

Authors:  R E Rennick; A Loesch; G Burnstock
Journal:  Thorax       Date:  1992-12       Impact factor: 9.139

2.  Flow-induced release of adenosine 5'-triphosphate from endothelial cells of the rat mesenteric arterial bed.

Authors:  V Ralevic; P Milner; K A Kirkpatrick; G Burnstock
Journal:  Experientia       Date:  1992-01-15

3.  An immunohistochemical study of endothelial cell heterogeneity in the rat: observations in "en face" Häutchen preparations.

Authors:  A Tomlinson; H Van Vlijmen; A Loesch; G Burnstock
Journal:  Cell Tissue Res       Date:  1991-01       Impact factor: 5.249

4.  Localization of arginine-vasopressin in endothelial cells of rat pulmonary artery.

Authors:  A Loesch; A Tomlinson; G Burnstock
Journal:  Anat Embryol (Berl)       Date:  1991

5.  Localisation of nitric oxide synthase and its colocalisation with vasoactive peptides in coronary and femoral arteries. An electron microscope study.

Authors:  K Dikranian; A Loesch; G Burnstock
Journal:  J Anat       Date:  1994-06       Impact factor: 2.610

6.  Activation of NTS A(1) adenosine receptors inhibits regional sympathetic responses evoked by activation of cardiopulmonary chemoreflex.

Authors:  Tomoko K Ichinose; Zeljka Minic; Cailian Li; Donal S O'Leary; Tadeusz J Scislo
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2012-07-18       Impact factor: 3.619

7.  Ultrastructural localisation of substance P and choline acetyltransferase in endothelial cells of rat coronary artery and release of substance P and acetylcholine during hypoxia.

Authors:  P Milner; V Ralevic; A M Hopwood; E Fehér; J Lincoln; K A Kirkpatrick; G Burnstock
Journal:  Experientia       Date:  1989-02-15

8.  Nucleus tractus solitarii A(2a) adenosine receptors inhibit cardiopulmonary chemoreflex control of sympathetic outputs.

Authors:  Zeljka Minic; Donal S O'Leary; Tadeusz J Scislo
Journal:  Auton Neurosci       Date:  2013-10-25       Impact factor: 3.145

9.  Localization of neuropeptide Y and atrial natriuretic peptide in the endothelial cells of human umbilical blood vessels.

Authors:  W Q Cai; P Bodin; A Sexton; A Loesch; G Burnstock
Journal:  Cell Tissue Res       Date:  1993-04       Impact factor: 5.249

10.  Effects of nitric oxide synthase inhibitors, L-NG-nitroarginine and L-NG-nitroarginine methyl ester, on responses to vasodilators of the guinea-pig coronary vasculature.

Authors:  A Vials; G Burnstock
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739
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