Literature DB >> 3691647

Balance between endothelium-mediated dilating and direct constricting actions of serotonin on resistance vessels in the isolated rabbit heart.

D J Stewart1, J Holtz, U Pohl, E Bassenge.   

Abstract

To determine whether endothelium-derived relaxing factor (EDRF) contributes to the vasomotor action of serotonin (5-HT) in the coronary resistance bed, we used haemoglobin as an inhibitor of EDRF in isolated perfused rabbit hearts. The 5-HT-induced dilatation (14 +/- 2% change in vascular resistance) was converted to constriction (10 +/- 3% change) in the presence of haemoglobin, while the vasodilator responses to papaverine were not attenuated. This is consistent with a role for EDRF in the mediation of 5-HT-induced coronary resistance vessel dilatation.

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Year:  1987        PMID： 3691647     DOI： 10.1016/0014-2999(87)90743-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Receptors mediating the effects of 5-hydroxytryptamine on the tracheal vasculature and smooth muscle of sheep.

Authors:  S E Webber; R O Salonen; J G Widdicombe
Journal:  Br J Pharmacol       Date:  1990-01       Impact factor: 8.739

2.  Alteration of vascular endothelium and endothelium smooth muscle interaction after carbogen gas perfusion of isolated rat and guinea pig heart.

Authors:  H Mertens; T Ballhausen; H G Hollweg; J C Kirkpatrick; H Kammermeier
Journal:  Basic Res Cardiol       Date:  1994 Jul-Aug       Impact factor: 17.165

3.  The role of nitric oxide in the initiation and in the duration of some vasodilator responses in the coronary circulation.

Authors:  D Gattullo; P Pagliaro; R J Linden; A Merletti; G Losano
Journal:  Pflugers Arch       Date:  1995-05       Impact factor: 3.657

4.  Catecholamine-induced cardiac necroses: protective effect of leucocytopenia, influence of an S2 antagonist, thromboxanesynthetase inhibitor and prostacycline analogue.

Authors:  L Classen; G Michalsky; H Kammermeier
Journal:  Basic Res Cardiol       Date:  1993 Jan-Feb       Impact factor: 17.165

Review 5.  Interdependence of pharmacologically-induced and endothelium-mediated coronary vasodilation in antianginal therapy.

Authors:  E Bassenge; D J Stewart
Journal:  Cardiovasc Drugs Ther       Date:  1988-05       Impact factor: 3.727

6.  Serotonin is localized in endothelial cells of coronary arteries and released during hypoxia: a possible new mechanism for hypoxia-induced vasodilatation of the rat heart.

Authors:  G Burnstock; J Lincoln; E Fehér; A M Hopwood; K Kirkpatrick; P Milner; V Ralevic
Journal:  Experientia       Date:  1988-08-15
  6 in total

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