Literature DB >> 2465912

Ultrastructural localisation of substance P and choline acetyltransferase in endothelial cells of rat coronary artery and release of substance P and acetylcholine during hypoxia.

P Milner1, V Ralevic, A M Hopwood, E Fehér, J Lincoln, K A Kirkpatrick, G Burnstock.   

Abstract

Substance P and choline acetyltransferase have been localised in a small proportion of endothelial cells of rat coronary arteries using electron microscopic immunocytochemistry. During a hypoxic period of 1 min, coronary vasodilatation was produced in the Langendorff heart preparation and increased levels of substance P and acetylcholine were released into the perfusate. The possibility that these substances are released from endothelial cells during hypoxia and contribute to the hyperaemic response is discussed.

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Year:  1989        PMID： 2465912     DOI： 10.1007/bf01954843

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  23 in total

1.  Autoradiographic demonstration of endothelium-dependent 125I-Bolton-Hunter substance P binding to dog carotid artery.

Authors:  J A Stephenson; E Burcher; R J Summers
Journal:  Eur J Pharmacol       Date:  1986-05-27       Impact factor: 4.432

2.  Histochemical and biochemical investigation of adrenergic, cholinergic and peptidergic innervation of the rat ventral prostate 8 weeks after streptozotocin-induced diabetes.

Authors:  R Crowe; P Milner; J Lincoln; G Burnstock
Journal:  J Auton Nerv Syst       Date:  1987-08

3.  Perfused rabbit heart: endothelium-derived relaxing factor in coronary arteries.

Authors:  M Saeed; J Schmidli; M Metz; R J Bing
Journal:  J Cardiovasc Pharmacol       Date:  1986 Mar-Apr       Impact factor: 3.105

4.  Ultrastructural localisation of serotonin and substance P in vascular endothelial cells of rat femoral and mesenteric arteries.

Authors:  A Loesch; G Burnstock
Journal:  Anat Embryol (Berl)       Date:  1988

5.  Substance P-immunoreactive nerve fibers in the heart.

Authors:  M Reinecke; E Weihe; W G Forssmann
Journal:  Neurosci Lett       Date:  1980-12       Impact factor: 3.046

6.  Production of specific antibodies to choline acetyltransferase purified from pig brain.

Authors:  F Eckenstein; Y A Barde; H Thoenen
Journal:  Neuroscience       Date:  1981       Impact factor: 3.590

7.  Isolated perfused rabbit coronary artery and aortic strip preparations: the role of endothelium-derived relaxant factor.

Authors:  T M Griffith; A H Henderson; D H Edwards; M J Lewis
Journal:  J Physiol       Date:  1984-06       Impact factor: 5.182

8.  ATP mediates coronary vasoconstriction via P2x-purinoceptors and coronary vasodilatation via P2y-purinoceptors in the isolated perfused rat heart.

Authors:  A M Hopwood; G Burnstock
Journal:  Eur J Pharmacol       Date:  1987-04-07       Impact factor: 4.432

9.  Endothelial cells are involved in the vasodilatory response to hypoxia.

Authors:  R Busse; U Pohl; C Kellner; U Klemm
Journal:  Pflugers Arch       Date:  1983-04       Impact factor: 3.657

10.  Serotonin is localized in endothelial cells of coronary arteries and released during hypoxia: a possible new mechanism for hypoxia-induced vasodilatation of the rat heart.

Authors:  G Burnstock; J Lincoln; E Fehér; A M Hopwood; K Kirkpatrick; P Milner; V Ralevic
Journal:  Experientia       Date:  1988-08-15
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  36 in total

Review 1.  Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction.

Authors:  G Burnstock
Journal:  J Anat       Date:  1999-04       Impact factor: 2.610

2.  Endothelium-dependent relaxation followed by contraction mediated by NK(1) receptors in precontracted rabbit intrapulmonary arteries.

Authors:  H Shirahase; M Kanda; K Kurahashi; S Nakamura
Journal:  Br J Pharmacol       Date:  2000-03       Impact factor: 8.739

3.  Endothelin, vasopressin, and substance P like immunoreactivity in cultured and intact epithelium from rabbit trachea.

Authors:  R E Rennick; A Loesch; G Burnstock
Journal:  Thorax       Date:  1992-12       Impact factor: 9.139

4.  Flow-induced release of adenosine 5'-triphosphate from endothelial cells of the rat mesenteric arterial bed.

Authors:  V Ralevic; P Milner; K A Kirkpatrick; G Burnstock
Journal:  Experientia       Date:  1992-01-15

5.  An immunohistochemical study of endothelial cell heterogeneity in the rat: observations in "en face" Häutchen preparations.

Authors:  A Tomlinson; H Van Vlijmen; A Loesch; G Burnstock
Journal:  Cell Tissue Res       Date:  1991-01       Impact factor: 5.249

6.  Localization of arginine-vasopressin in endothelial cells of rat pulmonary artery.

Authors:  A Loesch; A Tomlinson; G Burnstock
Journal:  Anat Embryol (Berl)       Date:  1991

7.  Real-time reverse transcription-PCR quantitation of substance P receptor (NK-1R) mRNA.

Authors:  Jian-Ping Lai; Steven D Douglas; Yan-Jian Wang; Wen-Zhe Ho
Journal:  Clin Diagn Lab Immunol       Date:  2005-04

Review 8.  Substance P in heart failure: the good and the bad.

Authors:  Heather M Dehlin; Scott P Levick
Journal:  Int J Cardiol       Date:  2013-11-12       Impact factor: 4.164

9.  Localization of neuropeptide Y and atrial natriuretic peptide in the endothelial cells of human umbilical blood vessels.

Authors:  W Q Cai; P Bodin; A Sexton; A Loesch; G Burnstock
Journal:  Cell Tissue Res       Date:  1993-04       Impact factor: 5.249

10.  The role of substance P in myocardial dysfunction during ischemia and reperfusion.

Authors:  H Chiao; R W Caldwell
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-03       Impact factor: 3.000
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