Literature DB >> 24574537

Chimeric plantibody passively protects mice against aerosolized ricin challenge.

Erin K Sully1, Kevin J Whaley, Natasha Bohorova, Ognian Bohorov, Charles Goodman, Do H Kim, Michael H Pauly, Jesus Velasco, Ernie Hiatt, Josh Morton, Kelsi Swope, Chad J Roy, Larry Zeitlin, Nicholas J Mantis.   

Abstract

Recent incidents in the United States and abroad have heightened concerns about the use of ricin toxin as a bioterrorism agent. In this study, we produced, using a robust plant-based platform, four chimeric toxin-neutralizing monoclonal antibodies that were then evaluated for the ability to passively protect mice from a lethal-dose ricin challenge. The most effective antibody, c-PB10, was further evaluated in mice as a therapeutic following ricin exposure by injection and inhalation.

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Year:  2014        PMID： 24574537      PMCID： PMC4018890          DOI： 10.1128/CVI.00003-14

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  36 in total

1.  Ribosome inactivation by the toxic lectins abrin and ricin. Kinetics of the enzymic activity of the toxin A-chains.

Authors:  S Olsnes; C Fernandez-Puentes; L Carrasco; D Vazquez
Journal:  Eur J Biochem       Date:  1975-12-01

2.  Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells.

Authors:  K Sandvig; S Olsnes; A Pihl
Journal:  J Biol Chem       Date:  1976-07-10       Impact factor: 5.157

Review 3.  Ribosome-inactivating proteins: progress and problems.

Authors:  F Stirpe; M G Battelli
Journal:  Cell Mol Life Sci       Date:  2006-08       Impact factor: 9.261

4.  RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol.

Authors:  Joan E Smallshaw; James A Richardson; Ellen S Vitetta
Journal:  Vaccine       Date:  2007-08-30       Impact factor: 3.641

5.  Protective effect of two recombinant ricin subunit vaccines in the New Zealand white rabbit subjected to a lethal aerosolized ricin challenge: survival, immunological response, and histopathological findings.

Authors:  Daniel E McLain; Bridget S Lewis; Jennifer L Chapman; Robert W Wannemacher; Changhong Y Lindsey; Leonard A Smith
Journal:  Toxicol Sci       Date:  2011-10-10       Impact factor: 4.849

6.  Effect of temperature on the uptake, excretion and degradation of abrin and ricin by HeLa cells.

Authors:  K Sandvig; S Olsnes
Journal:  Exp Cell Res       Date:  1979-06       Impact factor: 3.905

7.  Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques.

Authors:  Gene Garrard Olinger; James Pettitt; Do Kim; Cara Working; Ognian Bohorov; Barry Bratcher; Ernie Hiatt; Steven D Hume; Ashley K Johnson; Josh Morton; Michael Pauly; Kevin J Whaley; Calli M Lear; Julia E Biggins; Corinne Scully; Lisa Hensley; Larry Zeitlin
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-15       Impact factor: 11.205

8.  Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail.

Authors:  James Pettitt; Larry Zeitlin; Do H Kim; Cara Working; Joshua C Johnson; Ognian Bohorov; Barry Bratcher; Ernie Hiatt; Steven D Hume; Ashley K Johnson; Josh Morton; Michael H Pauly; Kevin J Whaley; Michael F Ingram; Ashley Zovanyi; Megan Heinrich; Ashley Piper; Justine Zelko; Gene G Olinger
Journal:  Sci Transl Med       Date:  2013-08-21       Impact factor: 17.956

9.  Localization of non-linear neutralizing B cell epitopes on ricin toxin's enzymatic subunit (RTA).

Authors:  Joanne M O'Hara; Jane C Kasten-Jolly; Claire E Reynolds; Nicholas J Mantis
Journal:  Immunol Lett       Date:  2013-11-21       Impact factor: 3.685

10.  The mechanism for activation of GTP hydrolysis on the ribosome.

Authors:  Rebecca M Voorhees; T Martin Schmeing; Ann C Kelley; V Ramakrishnan
Journal:  Science       Date:  2010-11-05       Impact factor: 47.728
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  27 in total

1.  Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies.

Authors:  Cristina Herrera; Jacqueline M Tremblay; Charles B Shoemaker; Nicholas J Mantis
Journal:  J Biol Chem       Date:  2015-09-22       Impact factor: 5.157

2.  Recent advances in the development of vaccines against ricin.

Authors:  Robert N Brey; Nicholas J Mantis; Seth H Pincus; Ellen S Vitetta; Leonard A Smith; Chad J Roy
Journal:  Hum Vaccin Immunother       Date:  2016-01-25       Impact factor: 3.452

3.  Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies.

Authors:  Andrea Bazzoli; David J Vance; Michael J Rudolph; Yinghui Rong; Siva Krishna Angalakurthi; Ronald T Toth; C Russell Middaugh; David B Volkin; David D Weis; John Karanicolas; Nicholas J Mantis
Journal:  Proteins       Date:  2017-08-04

4.  Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome.

Authors:  Amanda E Jetzt; Xiao-Ping Li; Nilgun E Tumer; Wendie S Cohick
Journal:  Toxicol Appl Pharmacol       Date:  2016-09-15       Impact factor: 4.219

5.  A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin.

Authors:  Erin K Sully; Kevin Whaley; Natasha Bohorova; Ognian Bohorov; Charles Goodman; Do Kim; Michael Pauly; Jesus Velasco; Frederick W Holtsberg; Eric Stavale; M Javad Aman; Chandra Tangudu; Francisco A Uzal; Nicholas J Mantis; Larry Zeitlin
Journal:  Toxicon       Date:  2014-09-28       Impact factor: 3.033

6.  A monoclonal antibody that targets the conserved core/lipid A region of lipopolysaccharide affects motility and reduces intestinal colonization of both classical and El Tor Vibrio cholerae biotypes.

Authors:  Kara J Levinson; Danielle E Baranova; Nicholas J Mantis
Journal:  Vaccine       Date:  2016-10-20       Impact factor: 3.641

7.  Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide.

Authors:  Kara J Levinson; Samantha R Giffen; Michael H Pauly; Do H Kim; Ognian Bohorov; Natasha Bohorova; Kevin J Whaley; Larry Zeitlin; Nicholas J Mantis
Journal:  J Immunol Methods       Date:  2015-04-09       Impact factor: 2.303

8.  High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine.

Authors:  Ronald T Toth; Siva Krishna Angalakurthi; Greta Van Slyke; David J Vance; John M Hickey; Sangeeta B Joshi; C Russell Middaugh; David B Volkin; David D Weis; Nicholas J Mantis
Journal:  Clin Vaccine Immunol       Date:  2017-12-05

9.  Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge.

Authors:  Greta Van Slyke; Erin K Sully; Natasha Bohorova; Ognian Bohorov; Do Kim; Michael H Pauly; Kevin J Whaley; Larry Zeitlin; Nicholas J Mantis
Journal:  Clin Vaccine Immunol       Date:  2016-09-06

Review 10.  Progress and challenges associated with the development of ricin toxin subunit vaccines.

Authors:  David J Vance; Nicholas J Mantis
Journal:  Expert Rev Vaccines       Date:  2016-04-06       Impact factor: 5.217
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