Literature DB >> 27466351

Humanized Monoclonal Antibody That Passively Protects Mice against Systemic and Intranasal Ricin Toxin Challenge.

Greta Van Slyke1, Erin K Sully1, Natasha Bohorova2, Ognian Bohorov2, Do Kim2, Michael H Pauly2, Kevin J Whaley2, Larry Zeitlin3, Nicholas J Mantis4.   

Abstract

PB10 is a murine monoclonal antibody against an immunodominant epitope on ricin toxin's enzymatic subunit. Here, we characterize a fully humanized version of PB10 IgG1 (hPB10) and demonstrate that it has potent in vitro and in vivo toxin-neutralizing activities. We also report the minimum serum concentrations of hPB10 required to protect mice against 10 times the 50% lethal dose of ricin when delivered by injection and inhalation.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 27466351      PMCID： PMC5014922          DOI： 10.1128/CVI.00088-16

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  18 in total

1.  Ribosome inactivation by the toxic lectins abrin and ricin. Kinetics of the enzymic activity of the toxin A-chains.

Authors:  S Olsnes; C Fernandez-Puentes; L Carrasco; D Vazquez
Journal:  Eur J Biochem       Date:  1975-12-01

2.  Kinetics of binding of the toxic lectins abrin and ricin to surface receptors of human cells.

Authors:  K Sandvig; S Olsnes; A Pihl
Journal:  J Biol Chem       Date:  1976-07-10       Impact factor: 5.157

3.  RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes.

Authors:  Y Endo; K Tsurugi
Journal:  J Biol Chem       Date:  1987-06-15       Impact factor: 5.157

4.  Comparative efficacy of two leading candidate ricin toxin a subunit vaccines in mice.

Authors:  Joanne M O'Hara; Robert N Brey; Nicholas J Mantis
Journal:  Clin Vaccine Immunol       Date:  2013-03-20

5.  Chimeric plantibody passively protects mice against aerosolized ricin challenge.

Authors:  Erin K Sully; Kevin J Whaley; Natasha Bohorova; Ognian Bohorov; Charles Goodman; Do H Kim; Michael H Pauly; Jesus Velasco; Ernie Hiatt; Josh Morton; Kelsi Swope; Chad J Roy; Larry Zeitlin; Nicholas J Mantis
Journal:  Clin Vaccine Immunol       Date:  2014-02-26

6.  Effect of temperature on the uptake, excretion and degradation of abrin and ricin by HeLa cells.

Authors:  K Sandvig; S Olsnes
Journal:  Exp Cell Res       Date:  1979-06       Impact factor: 3.905

7.  Plant-based expression of a partially humanized neutralizing monoclonal IgG directed against an immunodominant epitope on the ricin toxin A subunit.

Authors:  Joanne M O'Hara; Kevin Whaley; Michael Pauly; Larry Zeitlin; Nicholas J Mantis
Journal:  Vaccine       Date:  2011-12-22       Impact factor: 3.641

8.  Localization of non-linear neutralizing B cell epitopes on ricin toxin's enzymatic subunit (RTA).

Authors:  Joanne M O'Hara; Jane C Kasten-Jolly; Claire E Reynolds; Nicholas J Mantis
Journal:  Immunol Lett       Date:  2013-11-21       Impact factor: 3.685

9.  IgBLAST: an immunoglobulin variable domain sequence analysis tool.

Authors:  Jian Ye; Ning Ma; Thomas L Madden; James M Ostell
Journal:  Nucleic Acids Res       Date:  2013-05-13       Impact factor: 16.971

10.  Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin's Enzymatic Subunit Interfere with Intracellular Toxin Transport.

Authors:  Anastasiya Yermakova; Tove Irene Klokk; Joanne M O'Hara; Richard Cole; Kirsten Sandvig; Nicholas J Mantis
Journal:  Sci Rep       Date:  2016-03-07       Impact factor: 4.379
View more
  13 in total

1.  Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies.

Authors:  Andrea Bazzoli; David J Vance; Michael J Rudolph; Yinghui Rong; Siva Krishna Angalakurthi; Ronald T Toth; C Russell Middaugh; David B Volkin; David D Weis; John Karanicolas; Nicholas J Mantis
Journal:  Proteins       Date:  2017-08-04

2.  High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine.

Authors:  Ronald T Toth; Siva Krishna Angalakurthi; Greta Van Slyke; David J Vance; John M Hickey; Sangeeta B Joshi; C Russell Middaugh; David B Volkin; David D Weis; Nicholas J Mantis
Journal:  Clin Vaccine Immunol       Date:  2017-12-05

3.  An intranasally administered monoclonal antibody cocktail abrogates ricin toxin-induced pulmonary tissue damage and inflammation.

Authors:  Yinghui Rong; Fernando J Torres-Velez; Dylan Ehrbar; Jennifer Doering; Renjie Song; Nicholas J Mantis
Journal:  Hum Vaccin Immunother       Date:  2019-10-29       Impact factor: 3.452

4.  Multiple metabolic pathways are predictive of ricin intoxication in a rat model.

Authors:  Riccardo V D'Elia; Sarah A Goodchild; Catherine L Winder; Andrew D Southam; Ralf J M Weber; Fiona M Stahl; Cerys Docx; Vikesh Patel; A Christopher Green; Mark R Viant; Roman A Lukaszewski; Warwick B Dunn
Journal:  Metabolomics       Date:  2019-07-03       Impact factor: 4.290

5.  Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin's binding subunit.

Authors:  Yinghui Rong; Greta Van Slyke; David J Vance; Jennifer Westfall; Dylan Ehrbar; Nicholas J Mantis
Journal:  PLoS One       Date:  2017-07-10       Impact factor: 3.240

Review 6.  Toxin Neutralization Using Alternative Binding Proteins.

Authors:  Timothy Patrick Jenkins; Thomas Fryer; Rasmus Ibsen Dehli; Jonas Arnold Jürgensen; Albert Fuglsang-Madsen; Sofie Føns; Andreas Hougaard Laustsen
Journal:  Toxins (Basel)       Date:  2019-01-17       Impact factor: 4.546

Review 7.  Ricin: An Ancient Story for a Timeless Plant Toxin.

Authors:  Letizia Polito; Massimo Bortolotti; Maria Giulia Battelli; Giulia Calafato; Andrea Bolognesi
Journal:  Toxins (Basel)       Date:  2019-06-06       Impact factor: 4.546

8.  Sensitivity of Kupffer cells and liver sinusoidal endothelial cells to ricin toxin and ricin toxin-Ab complexes.

Authors:  Bridget Mooney; Fernando J Torres-Velez; Jennifer Doering; Dylan J Ehrbar; Nicholas J Mantis
Journal:  J Leukoc Biol       Date:  2019-07-16       Impact factor: 4.962

9.  Production, Characterisation and Testing of an Ovine Antitoxin against Ricin; Efficacy, Potency and Mechanisms of Action.

Authors:  Sarah J C Whitfield; Gareth D Griffiths; Dominic C Jenner; Robert J Gwyther; Fiona M Stahl; Lucy J Cork; Jane L Holley; A Christopher Green; Graeme C Clark
Journal:  Toxins (Basel)       Date:  2017-10-18       Impact factor: 4.546

10.  A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication.

Authors:  Yinghui Rong; Michael Pauly; Adrian Guthals; Henry Pham; Dylan Ehrbar; Larry Zeitlin; Nicholas J Mantis
Journal:  Toxins (Basel)       Date:  2020-03-29       Impact factor: 4.546
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.