Literature DB >> 25865265

Plant-based production of two chimeric monoclonal IgG antibodies directed against immunodominant epitopes of Vibrio cholerae lipopolysaccharide.

Kara J Levinson1, Samantha R Giffen2, Michael H Pauly3, Do H Kim3, Ognian Bohorov3, Natasha Bohorova3, Kevin J Whaley3, Larry Zeitlin3, Nicholas J Mantis4.   

Abstract

We have produced and characterized two chimeric human IgG1 monoclonal antibodies that bind different immunodominant epitopes on Vibrio cholerae lipopolysaccharide (LPS). MAb 2D6 IgG1 recognizes Ogawa O-polysaccharide antigen, while mAb ZAC-3 IgG1 recognizes core/lipid A moiety of Ogawa and Inaba LPS. Both antibodies were expressed using a Nicotiana benthamiana-based rapid antibody-manufacturing platform (RAMP) and evaluated in vitro for activities associated with immunity to V. cholerae, including vibriocidal activity, bacterial agglutination and motility arrest.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Antibodies; Cholera; Plant expression; Vaccine

Mesh：

Substances：

Year:  2015        PMID： 25865265      PMCID： PMC4458452          DOI： 10.1016/j.jim.2015.04.001

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  28 in total

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Review 3.  Cholera.

Authors:  Jason B Harris; Regina C LaRocque; Firdausi Qadri; Edward T Ryan; Stephen B Calderwood
Journal:  Lancet       Date:  2012-06-30       Impact factor: 79.321

4.  Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera.

Authors:  Russell A Johnson; Taher Uddin; Amena Aktar; M Mohasin; Mohammad Murshid Alam; Fahima Chowdhury; Jason B Harris; Regina C LaRocque; Meagan Kelly Bufano; Yanan Yu; Ying Wu-Freeman; Daniel T Leung; David Sarracino; Bryan Krastins; Richelle C Charles; Peng Xu; Pavol Kovác; Stephen B Calderwood; Firdausi Qadri; Edward T Ryan
Journal:  Clin Vaccine Immunol       Date:  2012-09-19

5.  Vibriocidal assays to determine the antibody titer of patient sera samples.

Authors:  Mike S Son; Ronald K Taylor
Journal:  Curr Protoc Microbiol       Date:  2011-11

6.  Role of FlgT in anchoring the flagellum of Vibrio cholerae.

Authors:  Raquel M Martinez; Brooke A Jude; Thomas J Kirn; Karen Skorupski; Ronald K Taylor
Journal:  J Bacteriol       Date:  2010-02-12       Impact factor: 3.490

7.  Characterization of a novel protective monoclonal antibody that recognizes an epitope common to Vibrio cholerae Ogawa and Inaba serotypes.

Authors:  Madushini N Dharmasena; Shelly J Krebs; Ronald K Taylor
Journal:  Microbiology (Reading)       Date:  2009-04-23       Impact factor: 2.777

8.  Cholera toxin-specific memory B cell responses are induced in patients with dehydrating diarrhea caused by Vibrio cholerae O1.

Authors:  Channa R Jayasekera; Jason B Harris; Saruar Bhuiyan; Fahima Chowdhury; Ashraful I Khan; Abu S G Faruque; Regina C Larocque; Edward T Ryan; Rafi Ahmed; Firdausi Qadri; Stephen B Calderwood
Journal:  J Infect Dis       Date:  2008-10-01       Impact factor: 5.226

9.  Evolutionary dynamics of Vibrio cholerae O1 following a single-source introduction to Haiti.

Authors:  Lee S Katz; Aaron Petkau; John Beaulaurier; Shaun Tyler; Elena S Antonova; Maryann A Turnsek; Yan Guo; Susana Wang; Ellen E Paxinos; Fabini Orata; Lori M Gladney; Steven Stroika; Jason P Folster; Lori Rowe; Molly M Freeman; Natalie Knox; Mike Frace; Jacques Boncy; Morag Graham; Brian K Hammer; Yan Boucher; Ali Bashir; William P Hanage; Gary Van Domselaar; Cheryl L Tarr
Journal:  MBio       Date:  2013-07-02       Impact factor: 7.867

10.  Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.

Authors:  Xiangguo Qiu; Gary Wong; Jonathan Audet; Alexander Bello; Lisa Fernando; Judie B Alimonti; Hugues Fausther-Bovendo; Haiyan Wei; Jenna Aviles; Ernie Hiatt; Ashley Johnson; Josh Morton; Kelsi Swope; Ognian Bohorov; Natasha Bohorova; Charles Goodman; Do Kim; Michael H Pauly; Jesus Velasco; James Pettitt; Gene G Olinger; Kevin Whaley; Bianli Xu; James E Strong; Larry Zeitlin; Gary P Kobinger
Journal:  Nature       Date:  2014-08-29       Impact factor: 49.962
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  7 in total

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Authors:  Kara J Levinson; Danielle E Baranova; Nicholas J Mantis
Journal:  Vaccine       Date:  2016-10-20       Impact factor: 3.641

2.  Transcriptional profiling of Vibrio cholerae O1 following exposure to human anti- lipopolysaccharide monoclonal antibodies.

Authors:  Danielle E Baranova; Graham G Willsey; Kara J Levinson; Carol Smith; Joseph Wade; Nicholas J Mantis
Journal:  Pathog Dis       Date:  2020-06-01       Impact factor: 3.166

3.  Multiple Modes of Action of a Monoclonal Antibody against Multidrug-Resistant Escherichia coli Sequence Type 131-H30.

Authors:  Luis M Guachalla; Katharina Hartl; Cecília Varga; Lukas Stulik; Irina Mirkina; Stefan Malafa; Eszter Nagy; Gábor Nagy; Valéria Szijártó
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191

4.  Vibrio cholerae O1 secretes an extracellular matrix in response to antibody-mediated agglutination.

Authors:  Danielle E Baranova; Kara J Levinson; Nicholas J Mantis
Journal:  PLoS One       Date:  2018-01-02       Impact factor: 3.240

5.  Impact of Immunoglobulin Isotype and Epitope on the Functional Properties of Vibrio cholerae O-Specific Polysaccharide-Specific Monoclonal Antibodies.

Authors:  Robert C Kauffman; Oluwaseyi Adekunle; Hanyi Yu; Alice Cho; Lindsay E Nyhoff; Meagan Kelly; Jason B Harris; Taufiqur Rahman Bhuiyan; Firdausi Qadri; Stephen B Calderwood; Richelle C Charles; Edward T Ryan; Jun Kong; Jens Wrammert
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6.  Inhibition of invasive salmonella by orally administered IgA and IgG monoclonal antibodies.

Authors:  Angelene F Richards; Jennifer E Doering; Shannon A Lozito; John J Varrone; Graham G Willsey; Michael Pauly; Kevin Whaley; Larry Zeitlin; Nicholas J Mantis
Journal:  PLoS Negl Trop Dis       Date:  2020-03-23

7.  Passive Immunity to Vibrio cholerae O1 Afforded by a Human Monoclonal IgA1 Antibody Expressed in Milk.

Authors:  Danielle E Baranova; Lihow Chen; Margaret Destrempes; Harry Meade; Nicholas J Mantis
Journal:  Pathog Immun       Date:  2020-05-08
  7 in total

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