Literature DB >> 24574525

Anabolic steroids abuse-induced cardiomyopathy and ischaemic stroke in a young male patient.

Reham Mohammed Shamloul1, Ahmed Fathy Aborayah, Assem Hashad, Foad Abd-Allah.   

Abstract

We report a case of a 37-year-old man presented with acute stroke and hepatorenal impairment which were associated with anabolic-androgenic steroids (AAS) abuse over 2 years. Despite the absence of apparent symptoms and signs of congestive heart failure at presentation, an AAS-induced dilated cardiomyopathy with multiple thrombi in the left ventricle was attributed to be the underlying cause of his condition. Awareness of the complications of AAS led to the prompt treatment of the initially unrecognised dilated cardiomyopathy, and improved the liver and kidney functions. However, the patient was exposed to a second severe ischaemic event, which led to his death. This unique and complex presentation of AAS complications opens for better recognition and treatment of their potentially fatal effects.

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Year:  2014        PMID: 24574525      PMCID: PMC3939390          DOI: 10.1136/bcr-2013-203033

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  13 in total

1.  Left ventricular early myocardial dysfunction after chronic misuse of anabolic androgenic steroids: a Doppler myocardial and strain imaging analysis.

Authors:  Antonello D'Andrea; Pio Caso; Gemma Salerno; Raffaella Scarafile; Giuseppe De Corato; Claudia Mita; Giovanni Di Salvo; Sergio Severino; Sergio Cuomo; Biagio Liccardo; Nicolino Esposito; Raffaele Calabrò
Journal:  Br J Sports Med       Date:  2006-12-18       Impact factor: 13.800

2.  Anabolic steroid use as the possible precipitant of dilated cardiomyopathy.

Authors:  P C Ferrera; D L Putnam; V P Verdile
Journal:  Cardiology       Date:  1997 Mar-Apr       Impact factor: 1.869

Review 3.  Medical issues associated with anabolic steroid use: are they exaggerated?

Authors:  Jay R Hoffman; Nicholas A Ratamess
Journal:  J Sports Sci Med       Date:  2006-06-01       Impact factor: 2.988

4.  Detrimental effects of anabolic steroids on human endothelial cells.

Authors:  Sandra D'Ascenzo; Danilo Millimaggi; Caterina Di Massimo; Gloria Saccani-Jotti; Francesco Botrè; Gaspare Carta; Maria Giuliana Tozzi-Ciancarelli; Antonio Pavan; Vincenza Dolo
Journal:  Toxicol Lett       Date:  2007-01-03       Impact factor: 4.372

Review 5.  The cardiac toxicity of anabolic steroids.

Authors:  M L Sullivan; C M Martinez; P Gennis; E J Gallagher
Journal:  Prog Cardiovasc Dis       Date:  1998 Jul-Aug       Impact factor: 8.194

Review 6.  Effects of androgenic-anabolic steroids in athletes.

Authors:  Fred Hartgens; Harm Kuipers
Journal:  Sports Med       Date:  2004       Impact factor: 11.136

Review 7.  Effects of androgens on haemostasis.

Authors:  U H Winkler
Journal:  Maturitas       Date:  1996-07       Impact factor: 4.342

Review 8.  Androgens and cardiovascular disease.

Authors:  Peter Y Liu; Alison K Death; David J Handelsman
Journal:  Endocr Rev       Date:  2003-06       Impact factor: 19.871

9.  Anabolic steroid-induced cardiomyopathy underlying acute liver failure in a young bodybuilder.

Authors:  Miguel Bispo; Ana Valente; Rosário Maldonado; Rui Palma; Helena Glória; João Nóbrega; Paula Alexandrino
Journal:  World J Gastroenterol       Date:  2009-06-21       Impact factor: 5.742

Review 10.  Anabolic steroids, acute myocardial infarction and polycythemia: a case report and review of the literature.

Authors:  Kathleen Stergiopoulos; Joseph J Brennan; Robin Mathews; John F Setaro; Smadar Kort
Journal:  Vasc Health Risk Manag       Date:  2008
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  13 in total

Review 1.  Doping with anabolic androgenic steroids (AAS): Adverse effects on non-reproductive organs and functions.

Authors:  Eberhard Nieschlag; Elena Vorona
Journal:  Rev Endocr Metab Disord       Date:  2015-09       Impact factor: 6.514

2.  Gerstmann syndrome complicating polycythemia secondary to anabolic steroid use.

Authors:  Nina Long; Satnaam Bassi; Don Pepito; Hossein Akhondi
Journal:  BMJ Case Rep       Date:  2019-06-06

Review 3.  Anabolic androgenic steroid abuse in the United Kingdom: An update.

Authors:  Carrie Mullen; Benjamin J Whalley; Fabrizio Schifano; Julien S Baker
Journal:  Br J Pharmacol       Date:  2020-03-03       Impact factor: 8.739

4.  Cardiomyopathy and heart failure secondary to anabolic-androgen steroid abuse.

Authors:  Onyedika J Ilonze; Chioma O Enyi; Chibuzo C Ilonze
Journal:  Proc (Bayl Univ Med Cent)       Date:  2022-03-17

5.  Anabolic androgenic steroid-induced acute myocardial infarction with multiorgan failure.

Authors:  Frederick J Flo; Obiajulu Kanu; Mohamed Teleb; Yuefeng Chen; Tariq Siddiqui
Journal:  Proc (Bayl Univ Med Cent)       Date:  2018-05-15

Review 6.  What does the research say about androgen use and cerebrovascular events?

Authors:  M Reza Sadaie; Mehdi Farhoudi; Masumeh Zamanlu; Nasser Aghamohammadzadeh; Atieh Amouzegar; Robert E Rosenbaum; Gary A Thomas
Journal:  Ther Adv Drug Saf       Date:  2018-05-08

7.  AMI and Anabolic-Androgenic Steroids: Case Report with Systematic Review.

Authors:  Eliana M Mustafa; Idiberto José Zotarelli Filho; Victor R R Ferreira; Sofia Braile Sabino; Giovanni B Sternieri; Luiza B Verdi; Cibele O V Queiroz; Bethina C Sbardellini; Maria C V B Braile-Sternieri
Journal:  Curr Cardiol Rev       Date:  2021

8.  Non-ischemic Cardiomyopathy Secondary to Left Ventricular Hypertrophy due to Long-term Anabolic-androgenic Steroid Use in a Former Olympic Athlete.

Authors:  Edward T Ha; Michael L Weinrauch; Jeffrey Brensilver
Journal:  Cureus       Date:  2018-09-17

Review 9.  A Mechanistic and Pathophysiological Approach for Stroke Associated with Drugs of Abuse.

Authors:  Aristides Tsatsakis; Anca Oana Docea; Daniela Calina; Konstantinos Tsarouhas; Laura-Maria Zamfira; Radu Mitrut; Javad Sharifi-Rad; Leda Kovatsi; Vasileios Siokas; Efthimios Dardiotis; Nikolaos Drakoulis; George Lazopoulos; Christina Tsitsimpikou; Panayiotis Mitsias; Monica Neagu
Journal:  J Clin Med       Date:  2019-08-23       Impact factor: 4.241

10.  Chronic high-dose testosterone treatment: impact on rat cardiac contractile biology.

Authors:  Munthana Wadthaisong; Namthip Witayavanitkul; Tepmanas Bupha-Intr; Jonggonnee Wattanapermpool; Pieter P de Tombe
Journal:  Physiol Rep       Date:  2019-07
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