Literature DB >> 24259990

Medical issues associated with anabolic steroid use: are they exaggerated?

Jay R Hoffman1, Nicholas A Ratamess.   

Abstract

For the past 50 years anabolic steroids have been at the forefront of the controversy surrounding performance enhancing drugs. For almost half of this time no attempt was made by sports governing bodies to control its use, and only recently have all of the major sports governing bodies in North America agreed to ban from competition and punish athletes who test positive for anabolic steroids. These punitive measures were developed with the primary concern for promotion of fair play and eliminating potential health risks associated with androgenic-anabolic steroids. Yet, controversy exists whether these testing programs deter anabolic steroid use. Although the scope of this paper does not focus on the effectiveness of testing, or the issue of fair play, it is of interest to understand why many athletes underestimate the health risks associated from these drugs. What creates further curiosity is the seemingly well-publicized health hazards that the medical community has depicted concerning anabolic steroidabuse. Is there something that the athletes know, or are they simply naïve regarding the dangers? The focus of this review is to provide a brief history of anabolic steroid use in North America, the prevalence of its use in both athletic and recreational populations and its efficacy. Primary discussion will focus on health issues associated with anabolic steroid use with an examination of the contrasting views held between the medical community and the athletes that are using these ergogenic drugs. Existing data suggest that in certain circumstances the medical risk associated with anabolic steroid use may have been somewhat exaggerated, possibly to dissuade use in athletes. Key PointsFor many years the scientific and medical communities depicted a lack of efficacy and serious adverse effects from anabolic steroid use.Clinical case studies continue to link anabolic steroid administration with myocardial infarct, suicide, and cancer, evidence to support a cause and effect relationship is lacking.It may be other contributing factors (i.e. genetic predisposition, diet, etc.) that play a substantial role and potentiate the harmful effects from anabolic steroids.

Entities:  

Keywords:  Androgens; athletes; ergogenic aids; performance enhancing drugs; sport supplements

Year:  2006        PMID: 24259990      PMCID: PMC3827559     

Source DB:  PubMed          Journal:  J Sports Sci Med        ISSN: 1303-2968            Impact factor:   2.988


  80 in total

1.  Is there a role for androgenic anabolic steroids in medical practice?

Authors:  A S Dobs
Journal:  JAMA       Date:  1999-04-14       Impact factor: 56.272

2.  Increased premature mortality of competitive powerlifters suspected to have used anabolic agents.

Authors:  M Pärssinen; U Kujala; E Vartiainen; S Sarna; T Seppälä
Journal:  Int J Sports Med       Date:  2000-04       Impact factor: 3.118

3.  Anabolic effects of nandrolone decanoate in patients receiving dialysis: a randomized controlled trial.

Authors:  K L Johansen; K Mulligan; M Schambelan
Journal:  JAMA       Date:  1999-04-14       Impact factor: 56.272

4.  Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV-related weight loss: a randomized controlled trial.

Authors:  A Strawford; T Barbieri; M Van Loan; E Parks; D Catlin; N Barton; R Neese; M Christiansen; J King; M K Hellerstein
Journal:  JAMA       Date:  1999-04-14       Impact factor: 56.272

5.  Anabolic steroid-induced hepatotoxicity: is it overstated?

Authors:  R D Dickerman; R M Pertusi; N Y Zachariah; D R Dufour; W J McConathy
Journal:  Clin J Sport Med       Date:  1999-01       Impact factor: 3.638

6.  Testosterone-propionate impairs the response of the cardiac capillary bed to exercise.

Authors:  C V Tagarakis; W Bloch; G Hartmann; W Hollmann; K Addicks
Journal:  Med Sci Sports Exerc       Date:  2000-05       Impact factor: 5.411

7.  The effects of 17 alpha-methyltestosterone on myocardial function in vitro.

Authors:  T LeGros; D McConnell; T Murry; M Edavettal; L A Racey-Burns; R E Shepherd; A H Burns
Journal:  Med Sci Sports Exerc       Date:  2000-05       Impact factor: 5.411

8.  Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: a randomized controlled trial.

Authors:  H G Pope; E M Kouri; J I Hudson
Journal:  Arch Gen Psychiatry       Date:  2000-02

9.  Ultrastructural analysis of ruptured tendon from anabolic steroid users.

Authors:  N A Evans; D J Bowrey; G R Newman
Journal:  Injury       Date:  1998-12       Impact factor: 2.586

10.  Psychosexual effects of three doses of testosterone cycling in normal men.

Authors:  W R Yates; P J Perry; J MacIndoe; T Holman; V Ellingrod
Journal:  Biol Psychiatry       Date:  1999-02-01       Impact factor: 13.382

View more
  16 in total

1.  National Athletic Trainers' Association position statement: anabolic-androgenic steroids.

Authors:  Robert D Kersey; Diane L Elliot; Linn Goldberg; Gen Kanayama; James E Leone; Mike Pavlovich; Harrison G Pope
Journal:  J Athl Train       Date:  2012 Sep-Oct       Impact factor: 2.860

2.  Effects of different doses of nandrolone decanoate on estrous cycle and ovarian tissue of rats after treatment and recovery periods.

Authors:  Vinícius Augusto Simão; Larissa Berloffa Belardin; Gabriel Adan Araújo Leite; Luiz Gustavo de Almeida Chuffa; Isabel Cristina Cherici Camargo
Journal:  Int J Exp Pathol       Date:  2015-11-17       Impact factor: 1.925

3.  Anabolic steroids abuse-induced cardiomyopathy and ischaemic stroke in a young male patient.

Authors:  Reham Mohammed Shamloul; Ahmed Fathy Aborayah; Assem Hashad; Foad Abd-Allah
Journal:  BMJ Case Rep       Date:  2014-02-26

Review 4.  Pharmacology of anabolic steroids.

Authors:  A T Kicman
Journal:  Br J Pharmacol       Date:  2008-06       Impact factor: 8.739

Review 5.  Can conditions of skeletal muscle loss be improved by combining exercise with anabolic-androgenic steroids? A systematic review and meta-analysis of testosterone-based interventions.

Authors:  Hugo Falqueto; Jorge L R Júnior; Mauro N O Silvério; Juliano C H Farias; Brad J Schoenfeld; Leandro H Manfredi
Journal:  Rev Endocr Metab Disord       Date:  2021-03-30       Impact factor: 6.514

Review 6.  Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecular mechanisms.

Authors:  Omar Ayaz; Susan Ellen Howlett
Journal:  Biol Sex Differ       Date:  2015-04-29       Impact factor: 5.027

7.  Chronic Exposure to Androgenic-Anabolic Steroids Exacerbates Axonal Injury and Microgliosis in the CHIMERA Mouse Model of Repetitive Concussion.

Authors:  Dhananjay R Namjoshi; Wai Hang Cheng; Michael Carr; Kris M Martens; Shahab Zareyan; Anna Wilkinson; Kurt A McInnes; Peter A Cripton; Cheryl L Wellington
Journal:  PLoS One       Date:  2016-01-19       Impact factor: 3.240

8.  Nutrition, Pharmacological and Training Strategies Adopted by Six Bodybuilders: Case Report and Critical Review.

Authors:  Paulo Gentil; Claudio Andre Barbosa de Lira; Antonio Paoli; José Alexandre Barbosa Dos Santos; Roberto Deivide Teixeira da Silva; José Romulo Pereira Junior; Edson Pereira da Silva; Rodrigo Ferro Magosso
Journal:  Eur J Transl Myol       Date:  2017-03-24

9.  Prevalence, Attitude, Knowledge, and Practice of Anabolic Androgenic Steroid (AAS) Use Among Gym Participants.

Authors:  Sami D Althobiti; Nassar M Alqurashi; Abdulmajeed S Alotaibi; Turki F Alharthi; Khaled A Alswat
Journal:  Mater Sociomed       Date:  2018-03

10.  Anabolic steroids in patients undergoing total knee arthroplasty.

Authors:  David Metcalfe; Evan Watts; James P Masters; Neil Smith
Journal:  BMJ Open       Date:  2012-09-22       Impact factor: 2.692

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.