| Literature DB >> 24568455 |
Fatemeh Sadat Tabatabaei Mirakabad1, Kazem Nejati-Koshki, Abolfazl Akbarzadeh, Mohammad Rahmati Yamchi, Mortaza Milani, Nosratollah Zarghami, Vahideh Zeighamian, Amirbahman Rahimzadeh, Somayeh Alimohammadi, Younes Hanifehpour, Sang Woo Joo.
Abstract
Poly (lactic-co-glycolic acid) (PLGA) is one of the most effective biodegradable polymeric nanoparticles (NPs). It has been approved by the US FDA to use in drug delivery systems due to controlled and sustained- release properties, low toxicity, and biocompatibility with tissue and cells. In the present review, the structure and properties of PLGA copolymers synthesized by ring-opening polymerization of DL-lactide and glicolide were characterized using 1H nuclear magnetic resonance spectroscopy, gel permeation chromatography, Fourier transform infrared spectroscopy and differential scanning calorimetry. Methods of preparation and characterization, various surface modifications, encapsulation of diverse anticancer drugs, active or passive tumor targeting and different release mechanisms of PLGA nanoparticles are discussed. Increasing experience in the application of PLGA nanoparticles has provided a promising future for use of these nanoparticles in cancer treatment, with high efficacy and few side effects.Entities:
Mesh：
Substances：
Year: 2014 PMID： 24568455 DOI： 10.7314/apjcp.2014.15.2.517
Source DB: PubMed Journal: Asian Pac J Cancer Prev ISSN： 1513-7368