| Literature DB >> 24556117 |
Gunjan Sarkar1, Nayan Ranjan Saha1, Indranil Roy1, Amartya Bhattacharyya1, Madhura Bose2, Roshnara Mishra2, Dipak Rana3, Debashis Bhattacharjee4, Dipankar Chattopadhyay5.
Abstract
The aim of this work is to examine the effectiveness of mucilage/hydroxypropylmethylcellulose (HPMC) based transdermal patch (matrix type) as a drug delivery device. We have successfully extracted mucilage from Colocasia esculenta (Taro) corms and prepared diltiazem hydrochloride incorporated mucilage/HPMC based transdermal patches using various wt% of mucilage by the solvent evaporation technique. Characterization of both mucilage and transdermal patches has been done by several techniques such as Molisch's test, organoleptic evaluation of mucilage, mechanical, morphological and thermal analysis of transdermal patches. Skin irritation test is studied on hairless Albino rat skin showing that transdermal patches are apparently free of potentially hazardous skin irritation. Fourier transform infrared analysis shows that there is no interaction between drug, mucilage and HPMC while scanning electron microscopy shows the surface morphology of transdermal patches. In vitro drug release time of mucilage-HPMC based transdermal patches is prolonged with increasing mucilage concentration in the formulation.Entities:
Keywords: In vitro drug release; Mechanical properties; Mucilage; Skin irritation test; Transdermal patch
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Year: 2014 PMID： 24556117 DOI： 10.1016/j.ijbiomac.2014.02.024
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953