Literature DB >> 2455024

Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain.

J N Wilcox1, R Derynck.   

Abstract

The distribution of transforming growth factor (TGF)-alpha and TGF-beta 1 mRNA containing cells in adult mouse brain was examined using in situ hybridization histochemistry. There were no detectable TGF-beta 1 mRNA-containing cells found in the brain. TGF-alpha mRNA was localized to cell bodies of the caudate nucleus, dentate gyrus, anterior olfactory nuclei, and a laminar distribution of mitral cells in the olfactory bulb. TGF-alpha-synthesizing cells were localized in brain regions that have been shown to synthesize nerve growth factor, epidermal growth factor (EGF) and enkephalins. The function of local synthesis of TGF-alpha in the brain is as yet unknown.

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Year:  1988        PMID： 2455024      PMCID： PMC6569313     

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  28 in total

Review 1.  Roles of transforming growth factor-alpha and related molecules in the nervous system.

Authors:  C J Xian; X F Zhou
Journal:  Mol Neurobiol       Date:  1999 Oct-Dec       Impact factor: 5.590

2.  Expression of transforming growth factor alpha in human tissues: immunohistochemical study and northern blot analysis.

Authors:  W Yasui; Z Q Ji; H Kuniyasu; A Ayhan; H Yokozaki; H Ito; E Tahara
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992

3.  Serum and transforming growth factor beta regulate glial fibrillary acidic protein in serum-free-derived mouse embryo cells.

Authors:  Y Sakai; C Rawson; K Lindburg; D Barnes
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

4.  Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma.

Authors:  V Tropepe; C G Craig; C M Morshead; D van der Kooy
Journal:  J Neurosci       Date:  1997-10-15       Impact factor: 6.167

5.  Hydrolysis of transforming growth factor-alpha by cell-surface peptidases in vitro.

Authors:  Y Choudry; A J Kenny
Journal:  Biochem J       Date:  1991-11-15       Impact factor: 3.857

6.  Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes.

Authors:  R Ebner; R Derynck
Journal:  Cell Regul       Date:  1991-08

7.  The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.

Authors:  E B Jakobovits; U Schlokat; J L Vannice; R Derynck; A D Levinson
Journal:  Mol Cell Biol       Date:  1988-12       Impact factor: 4.272

8.  Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.

Authors:  J N Wilcox; K M Smith; L T Williams; S M Schwartz; D Gordon
Journal:  J Clin Invest       Date:  1988-09       Impact factor: 14.808

9.  Effect of transforming growth factor-alpha on gastric acid secretion in rats and monkeys.

Authors:  A Guglietta; C A Lesch; M Romano; R W McClure; R J Coffey
Journal:  Dig Dis Sci       Date:  1994-01       Impact factor: 3.199

10.  TGF-alpha increases human mesenchymal stem cell-secreted VEGF by MEK- and PI3-K- but not JNK- or ERK-dependent mechanisms.

Authors:  Yue Wang; Paul R Crisostomo; Meijing Wang; Troy A Markel; Nathan M Novotny; Daniel R Meldrum
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-08-06       Impact factor: 3.619
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