Literature DB >> 2843568

Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.

J N Wilcox1, K M Smith, L T Williams, S M Schwartz, D Gordon.   

Abstract

Platelet-derived growth factor (PDGF) mRNA, and mRNA for its receptor, have been localized to specific cell types within the human atherosclerotic plaque, using in situ hybridization. The predominant cell types found to express PDGF A and B chain mRNA are mesenchymal-appearing intimal cells and endothelial cells, respectively, with little or no expression detected in macrophages. The distribution of PDGF receptor mRNA containing cells was also examined and found to be localized predominantly in the plaque intima.

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Year:  1988        PMID： 2843568      PMCID： PMC303629          DOI： 10.1172/JCI113671

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  60 in total

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10.  Ulex europaeus I lectin as a marker for vascular endothelium in human tissues.

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  107 in total

Review 1.  Molecular aspects of pathological processes in the artery wall.

Authors:  J W van Neck; H P Bloemers
Journal:  Mol Biol Rep       Date:  1992-11       Impact factor: 2.316

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Authors:  V W van Hinsbergh
Journal:  Mol Cell Biochem       Date:  1992-10-21       Impact factor: 3.396

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Journal:  Br Heart J       Date:  1990-12

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Authors:  S M Schwartz; L Foy; D F Bowen-Pope; R Ross
Journal:  Am J Pathol       Date:  1990-06       Impact factor: 4.307

6.  Expression of platelet derived growth factor B chain and beta receptor in human coronary arteries after percutaneous transluminal coronary angioplasty: an immunohistochemical study.

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Journal:  Heart       Date:  1996-06       Impact factor: 5.994

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Authors:  J Fingerle; R Johnson; A W Clowes; M W Majesky; M A Reidy
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

8.  Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque.

Authors:  J N Wilcox; K M Smith; S M Schwartz; D Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

9.  Chronic insulin treatment amplifies PDGF-induced motility in differentiated aortic smooth muscle cells by suppressing the expression and function of PTP1B.

Authors:  Daming Zhuang; Qinghua Pu; Bogdan Ceacareanu; Yingzi Chang; Madhulika Dixit; Aviv Hassid
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-05-02       Impact factor: 4.733

10.  Tissue localization of beta receptors for platelet-derived growth factor and platelet-derived growth factor B chain during wound repair in humans.

Authors:  C Reuterdahl; C Sundberg; K Rubin; K Funa; B Gerdin
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808
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