Noise and signal power and their effects on evoked potential estimation.

Signal power, noise power and their ratio (SNR) are important variables underlying estimation of evoked potential signals, yet, they are rarely explicitly considered in the design or analysis of EP experiments. A model is developed which relates the reliability of the average evoked potential (AEP) wave form to signal power, noise power, SNR, and the number of single trials included in the average. Measurements taken from auditory and visual EP experiments in elderly subjects show that noise power is highly reliable across experimental conditions and probably reflects global CNS anatomic or physiologic factors. In contrast, signal power and SNR are variable across conditions and sensory modalities, but are stable across replications. Thus signal power reflects CNS processes specific to the experimental paradigm. These results have importance for EP estimation. The expected reliability of the AEP cannot be adequately predicted from estimates of a subject's noise power, or from SNR estimated under different experimental conditions. These findings suggest the need for on-line estimation of SNR during data acquisition to ensure adequate reliability of AEPs.