Literature DB >> 24515950

Near infrared light-triggered drug generation and release from gold nanoparticle carriers for photodynamic therapy.

Yu Cheng1, Tennyson L Doane, Chi-Hung Chuang, Assem Ziady, Clemens Burda.   

Abstract

A photoprecursor Pc 227 is covalently bound onto gold nanoparticles (Au NPs) to produce the known photodynamic therapy (PDT) drug Pc 4 upon 660 nm photoirradiation. The photochemical formation of the photoproduct Pc 4 is identified by spectroscopy, chromatography, and mass spectrometry and its PDT efficacy is equal to Pc 4 when administered non-covalently by Au NPs, with the added benefit of improved covalent delivery and targeted NIR-triggered release from the covalent Pc 227-Au NP conjugate, while during transport the attached Pc 227 is quenched by the Au NP and PDT inactivated.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  caged drug; gold nanoparticle; photodynamic therapy; phototriggered release

Mesh：

Substances：

Year:  2014        PMID： 24515950      PMCID： PMC4013205          DOI： 10.1002/smll.201303329

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


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