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Literature DB >> 31372221

Hyaluronic Acid Grafted Nanoparticles of a Platinum(II)-Silicon(IV) Phthalocyanine Conjugate for Tumor and Mitochondria-Targeted Photodynamic Therapy in Red Light.

Koushambi Mitra^1,2, Montserrat Samso³, Charles E Lyons², Matthew C T Hartman^1,2.

Abstract

Herein, we report novel hyaluronic acid formulated nanoparticles containing a platinum(II) conjugated silicon(IV) phthalocyanine (SiPc-Pt-HA) for tumor targeted red light photodynamic therapy and chemotherapy. The SiPc-Pt-HA conjugate showed specific uptake, photo-enhanced cytotoxicity (~1500 fold) and mitochondrial accumulation in breast cancer over normal cells.

Entities: CellLine Chemical Disease Gene Species

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Year: 2018 PMID： 31372221 PMCID： PMC6675464 DOI： 10.1039/C8TB02533A

Source DB: PubMed Journal: J Mater Chem B ISSN： 2050-750X Impact factor: 6.331

51 in total

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Journal: Chem Rev Date: 2010-05-12 Impact factor: 60.622

2. Platinum complexes as light promoted anticancer agents: a redefined strategy for controlled activation.

Authors: Koushambi Mitra
Journal: Dalton Trans Date: 2016-12-06 Impact factor: 4.390

3. Hematoporphyrin-derived soluble porphyrin-platinum conjugates with combined cytotoxic and phototoxic antitumor activity.

Authors: Christian Lottner; Karl-Christian Bart; Günther Bernhardt; Henri Brunner
Journal: J Med Chem Date: 2002-05-09 Impact factor: 7.446

4. Silicon phthalocyanine (Pc 4) photodynamic therapy is a safe modality for cutaneous neoplasms: results of a phase 1 clinical trial.

Authors: Elma D Baron; Christi L Malbasa; Diana Santo-Domingo; Pingfu Fu; Janine D Miller; Kaija K Hanneman; Andrew H Hsia; Nancy L Oleinick; Valdir C Colussi; Kevin D Cooper
Journal: Lasers Surg Med Date: 2010-12 Impact factor: 4.025

5. Molecular combo of photodynamic therapeutic agent silicon(iv) phthalocyanine and anticancer drug cisplatin.

Authors: Jiafei Mao; Yangmiao Zhang; Jianhui Zhu; Changli Zhang; Zijian Guo
Journal: Chem Commun (Camb) Date: 2009-01-19 Impact factor: 6.222

6. Near infrared fluorescent nanoparticles based on hyaluronic acid: Self-assembly, optical properties, and cell interaction.

Authors: Sneha S Kelkar; Tanner K Hill; Frank C Marini; Aaron M Mohs
Journal: Acta Biomater Date: 2016-03-17 Impact factor: 8.947

7. A Mitochondria-Targeted Photosensitizer Showing Improved Photodynamic Therapy Effects Under Hypoxia.

Authors: Wen Lv; Zhang Zhang; Kenneth Yin Zhang; Huiran Yang; Shujuan Liu; Aqiang Xu; Song Guo; Qiang Zhao; Wei Huang
Journal: Angew Chem Int Ed Engl Date: 2016-07-06 Impact factor: 15.336

Review 8. Multi-platinum anti-cancer agents. Substitution-inert compounds for tumor selectivity and new targets.

Authors: N P Farrell
Journal: Chem Soc Rev Date: 2015-05-08 Impact factor: 54.564

Review 9. Dye Sensitizers for Photodynamic Therapy.

Authors: Alexandra B Ormond; Harold S Freeman
Journal: Materials (Basel) Date: 2013-03-06 Impact factor: 3.623

10. In-Cell Activation of Organo-Osmium(II) Anticancer Complexes.

Authors: Russell J Needham; Carlos Sanchez-Cano; Xin Zhang; Isolda Romero-Canelón; Abraha Habtemariam; Margaret S Cooper; Levente Meszaros; Guy J Clarkson; Philip J Blower; Peter J Sadler
Journal: Angew Chem Int Ed Engl Date: 2016-12-21 Impact factor: 15.336

4 in total